生精片治疗特发性弱精子症的临床研究

Study on Shengjing Pian in patients with idiopathic asthenozoospermia

目的:探讨生精片对特发性弱精子症的治疗作用。方法:特发性弱精子症患者126例,年龄(31±5.6)岁。按照随机对照研究原则分为2组。治疗组65例,服用生精片;对照组61例,服用五子衍宗口服液;均连续服用90d。试验前90d为洗脱期。所有患者服药前、后均使用CASA检测2次精液质量,取各参数值的平均值进行统计学分析。结果:治疗组a级精子比率、前向运动精子比率(PR)、PR精子总数/次射精较治疗前均有明显增加,差异具有统计学意义(P<0.05),而对照组治疗前后差异无统计学意义;与对照组比较,治疗组显效率、有效率以及总有效率差异均具有统计学意义(P<0.01);治疗后,两组间a级精子比率及/或PR精子比率差异显著,具有统计学意义(P<0.05)。结论:生精片能够改善精子活力,可以用于治疗特发性弱精子症。

Objective： To discuss the efficacy of Shengjing Pian in treatment of patients with idiopathic asthenozoospermia.Methods： A total of 126 patients with idiopathic asthenozoospermia,diagnosed with the computer-assisted semen analysis system（CASA） and the WHO guide lines,were enrolled in a double blind clinical trial.All patients were randomized into two groups,65 patients in Shengjing Pian group（treatment group） and 61 patients in Wuziyanzong Oral group（control group）,both for a course of 90 days.Efficacy and adverse effects were evaluated with CASA after treatment to analyzed the changes in sperm concentration and percentage of grade a and PR sperm in the patients.Results： There was significant difference in percentage of grade a,and PR sperm in the patients of the trial group after 90 days medication（P0.05）,and the control group patients showed no significant difference.The efficiency,effective rate and total efficiency of the treatment group were higher than that of the control group,the differences were statistically significant（P0.01）.Conclusion： Shengjing Pian can improve sperm motility and can be used for the treatment of idiopathic asthenospermia.