磷酸肌酸钠对新生儿心肌损伤的疗效观察

Clinical Observation on Creatine Phosphate Sodium in Treatment of Newborn′s Myocardial Damage

目的探讨磷酸肌酸钠治疗新生儿心肌损害的临床疗效。方法将40例新生儿心肌损害患儿随机分为试验组和对照组(各20例),两组均采取相同的综合治疗,试验组加用注射用磷酸肌酸钠治疗;对照组加用1,6-二磷酸果糖治疗。比较两组治疗前后心肌肌钙蛋白T、乳酸脱氢酶同工酶和磷酸肌酸激酶同工酶的变化。结果两组治疗前后心肌肌钙蛋白T、乳酸脱氢酶同工酶和磷酸肌酸激酶同工酶比较差异有统计学意义(P<0.05);试验组总有效率为90%,对照组为60%,差异有统计学意义(P<0.05)。结论磷酸肌酸钠治疗新生儿心肌损害疗效显著,磷酸肌酸钠能对新生儿心肌损害具有保护、促进心肌组织及心功能恢复的作用,值得临床推广。

Objective To explore clinical curative effect of creatine phosphate sodium in treatment of newborn′s myocardial damage.Methods 40 cases of newborns with myocardial damage were retrospectively analyzed.They were randomly divided into the observation group and control group（20 cases each）,both groups were geiven the same comprehensive treatment,and the observation group was given extra creatine phosphate sodium through injection,the control group was given fructose-1,6-diphosphate（FDP）treatment.Results Cardiac troponin T,lactate dehydrogenase isoenzymes（LDH-1）and phosphoric acid creatine kinase isozymes（CK-MB）of the two groups before and a week after treatment were statistically significantly different（P0.05）;total effective rate of the observation group was 90%,and of the control group was 60%,the difference was statistically significant（P0.05）.Conclusion Creatine phosphate sodium has significant effect in treatment of newborn′s myocardial damage,which can protect the newborn from myocardial injury,promote myocardial tissue and cardiac function recovery,thus is worth of clinical promotion.