血清尿酸水平与心房颤动的关系

Serum Uric Acid Level and Atrial Fibrillation

目的探究血尿酸水平与心房颤动(简称房颤)的关系。方法将116例房颤患者根据房颤类型分为阵发性房颤组(53例)和持续性房颤组(63例)。选择同期在重庆市开县人民医院体检的78例健康体检者作为对照组。分别测量三组的血尿酸、心脏彩超,并记录既往患病史及用药情况。结果三组在年龄、运用β受体阻滞剂、左心室射血分数(LVEF)、左心房直径、尿酸水平方面比较差异有统计学意义(P<0.05);单因素回归分析显示,年龄、运用β受体阻滞剂、LVEF、左心房直径、尿酸水平与房颤发生显著相关(P<0.01);多因素Logistic回归分析显示,尿酸水平和LVEF是房颤发生的独立危险因素(P<0.01)。结论血清尿酸是一个简便的且较容易监测的房颤危险因子,可以作为研究房颤发病机制的一个研究方向。

Objective To investigate the correlation of serum uric acid level and atrial fibrillation（AF）.Methods 116 cases of AF patients were divided into paroxysmal AF group（53 cases）and persistent AF group（63 cases）.78 cases for physical examination in Chongqing Kaixian People′s Hospital of the same period were selected as the control group.Blood uric acid,echocardiography and previous medical history and medication of every object were measured/recorded.Results Statistically significant differences in age,use of beta blockers,left ventricular ejection fraction,left atrial diameter,and uric acid levels were seen between the three groups（P0.05）.Single factor regression analysis showed,age,use of beta blockers,left ventricular ejection fraction,left atrial diameter,uric acid,and occurrence of atrial fibrillation were significantly related（P0.01）.Multivariate logistic regression analysis showed,uric acid levels and left ventricular ejection fraction were independent risk factor for atrial fibrillation（P0.01）.Conclusion The serum uric acid is a simple,easier to monitor AF risk factor,which can be a research direction for the study of AF pathogenesis.