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维生素D对糖尿病肾病的保护作用 被引量：6

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摘要 维生素D又称抗佝偻病维生素．是一种类固醇激素，主要来源于皮肤经紫外线照射后合成，少数来自于饮食摄取。维生素D只有经过羟化酶的催化才具有生物活性。
作者 黄水金 赖晓阳
机构地区 南昌大学医学院研究生院 南昌大学第二附属医院内分泌与代谢科
出处 《江西医药》 CAS 2012年第10期939-942,共4页 Jiangxi Medical Journal
关键词 糖尿病 糖尿病肾病 维生素D
分类号 R587.1 [医药卫生—内分泌]
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参考文献18

  • 1PittasA G,Sun Q,Manson J E,et al. Plasma 25 -hydroxyvitamin Dconcentration and risk of incident type 2 diabetes in women.Dia-betes Care ,2010, 33:2021.
  • 2PamelaR,von Hurst, Welma Stonehouse.Vitamin D supplementationreduces insulin resistance in South Asian women living in NewZealand who are insulin resistant and vitamin D defcient -arandomised, placebo-controlled trial.Nutr,2010,103:549.
  • 3TracySMoreira’Mazen J,Hamadeh. The role of vitamin D defciencyin the pathogenesis of type 2 diabetes mellitus. European e -Journal of Clin Nutr and Meta, 2010,5:e 155.
  • 4HeidiWolden -Kirk ,Lut Overbergh, Henrik Thybo Christesen.Vitamin D and diabetes: Its importance for beta cell and immunefunction.Molecular and Cellular Endocrinology ,2011,347:106.
  • 5RabinovitchA, Suarez -Pinzon WL, Sooy K, et al.Expression ofcalbindin -D (28k) in a pancreatic islet beta -cell line protectsagainst cytokine -induced apoptosis and necrosis. Endocrinology,2001,142:3649.
  • 6Dilip K Deb, Yunzi Chen, Zhongyi Zhang, et al. 1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-KB pathway.Physiol Renal Physiol,2009,296(5): F1212.
  • 7MarioCozzolino,FlorjanMehmeti, Paola Ciceri,et al. The Effect ofParicalcitol on Vascular Calcifcation and Cardiovascular Diseasein Uremia: Beyond PTH Control.Inj Nephrol,2011, 2011 : 269060.
  • 8JohnP Forman, Jonathan S Williams,Naomi DL Fisher. Plasma 25-hydroxyvitamin D and regulation of the Renin Angiotensin Systemin Humans.Hypertension,2010,55(5): 1283.
  • 9ZhongyiZhang, Yan Zhang, Gang Ning, et al. Combination therapywith ATI blocker and vitamin D analog markedly amelioratesdiabetic nephropathy:Blockade of compensatory renin increase.PNAS ,2008,14:15896.
  • 10Ikko Ohara, Mitsuo Tanimoto, Tomohito Gohda. Effect ofCombination Therapy with Angiotensin Receptor Blocker and 1,25 -Dihydroxyvitamin D3 in Type 2 Diabetic Nephropathy in KK-iVy/Ta Mice.Nephron Exp Nephrol,2011,117:el24.

同被引文献98

  • 1张春,朱忠华,刘建社,杨晓,邓安国.结缔组织生长因子对肾小管上皮细胞转分化的调节机制[J].中华医学杂志,2005,85(41):2920-2925. 被引量：22
  • 2周月宏,王秋月.CTGF在糖尿病肾病发病机制中的作用及意义[J].国际内分泌代谢杂志,2006,26(4):273-276. 被引量：20
  • 3杨勤,谢汝佳,韩冰,肖瑛,杨婷,方丽,龙义国,张国忠.转化生长因子胞内信号蛋白Smad2/3在糖尿病大鼠肾脏表达的动态观察及意义研究[J].中国病理生理杂志,2006,22(10):1879-1884. 被引量：21
  • 4Martinez-Salgado C, Fuentes-Calvo I, Garcia-Cenador B, et al. Involvement of H- and N-Ras isoforms in transforming growth factor- betal-induced proliferation and in collagen and fibronectin synthesis [ J]. Exp Cell Res, 2006,312( 11 ) :2093-2106.
  • 5Kattla JJ, Carew RM, Heljic M, et al. Protein kinase B/Akt activity is involved in renal TGF-betal-driven epithelial-mesenchymal transition in vitro and in vivo [ J ]. Am J Physiol Renal Physiol, 2008,295 ( 1 ) : F215-F225.
  • 6Lee TN, Alborn WE, Knierman MD, et al. The diabetogenic antibiotic streptozotocin modifies the tryptic digest pattern for peptides of the enzyme O-GlcNAc-selective N-acetyl-beta-d-glucosaminidase that contain amino acid residues essential for enzymatic activity [ J ]. Biochem Pharmacol, 2006,72 ( 6 ) :710-718.
  • 7Evans JL, Goldfine ID, Maddux BA, et al. Oxidative stress and stress- activated signaling pathways : a unifying hypothesis of type 2 diabetes [J]. Endocr Rev, 2002,23(5) :599-622.
  • 8Ziyadeh FN. Mediators of diabetic renal disease : the ease for TGF-beta as the major mediator[ J]. J Am Soc Nephrol, 2004,15 ( Suppl 1 ) : $55-$57.
  • 9Fraser D, Brunskill N, Ito T, et al. Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor- beta 1 synthesis via an autoerine PDGF loop J . Am J Pathol, 2003, 163 ( 6 ) :2565-2574.
  • 10Karakus SC, Turkyilmaz Z, Sonmez K, et al. The effect of enalapril on renal resistive index, urine electrolyte levels and TGF-betal levels of kidney tissues in rats with unilateral partial ureteropelvic junction obstruction[ J]. Eur J Pediatr Surg, 2011,21 (6) :356-361.

引证文献6

二级引证文献34

江西医药
2012年 第10期

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