摘要
目的观察替吉奥(S-1)胶囊联合奥沙利铂方案治疗晚期胃癌的临床疗效及不良反应。方法 35例晚期胃癌患者,采用以下方案化疗。替吉奥胶囊每天80 mg/m2,分2次,餐后口服,第1~14天;奥沙利铂130 mg/m2,静脉滴注2 h,21天为1个周期,至少完成2个周期。按RECIST 1.1标准评价客观疗效和不良反应。结果 35例患者均可以评价疗效。PR 16例(45.7%),SD 11例(31.4%),PD 8例(22.9%)。不良反应主要是骨髓抑制,胃肠道反应及外周神经毒性。结论奥沙利铂联合替吉奥方案治疗晚期胃癌的近期疗效较好,不良反应可以耐受,值得进一步临床研究应用。
Objective To evaluate the efficacy and toxicity of oxaliplatin combined with S-1 capsule in the treatment of advanced gastric cancer patients.Methods 35 patients with advanced gastric cancer were treated with chemotherapy consisting of S-1 capsule 80 mg/m2 twice daily for 14 days and intravenously oxaliplatin 130 mg /m2 in days 1,administered every 21 days for at least 2 cycles.Efficacy and toxicities were evaluated according to the RECIST1.1standard.Results Of the 35 patients,there were 16(45.7%) partial remission(PR),11(31.4%) stable disease(SD),and 8(22.9%) progression disease(PD).The major toxicities included leucopenia,nausea,vomiting and neurosensory abnormity.Conclusion Oxaliplatin combined with S1 capsule have good efficacy with accepted toxicities in treating patients with advanced gastric cancer.
出处
《实用癌症杂志》
2012年第6期600-601,共2页
The Practical Journal of Cancer
关键词
替吉奥
奥沙利铂
晚期胃癌
S-1
Oxaliplatin
Advanced gastric carcinoma