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循环核酸在癌症中的研究进展

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摘要 循环核酸是指存在于血浆或血清等体液中的细胞外游离状态的核酸。早在1948年,Mandel与Métais[1]首次发现了人类血液中循环核酸的存在,但当时并未引起学术界太大的关注。直到1994年,肿瘤患者血液中RAS基因片段的检测及应用[2],医学界才重新认识到循环核酸的重要性。
作者 范洪君 刘风玲
机构地区 河北医科大学第四医院肿瘤内科
出处 《实用癌症杂志》 2012年第6期680-682,共3页 The Practical Journal of Cancer
关键词 循环核酸 癌症 肿瘤标志物
分类号 R730.2 [医药卫生—肿瘤]
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参考文献36

  • 1Mandel P, M6tais P. Les acides nucl' eiques du plasma sanguin chez 1' homme[J]. C R Hebd Seances Acad Sci (Paris), 1948,142 (3 - 4) :241.
  • 2Vasioukhin V, Anker P, Maurice P, et al. Point mutations of the N-ras genein the blood plasma DNA of patients with myelodysplastic syn- drome or acute myelogenous leukaemia [ J ]. Br J Haematol, 1994,86 (4-) :774.
  • 3Tan Eng M, Pierre R. Deoxyribonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosusand other disease [J]. J Clin Invest, 1966,45 ( 11 ) : 1732.
  • 4Stroun M, Anker P, Mauriee P, et al. Neoplastic characteristics of the DNA found in the plasma of cancer patients [J]. Oncology, 1989,46 (5) :318.
  • 5Chen X Q, Stroun M, Magnenat J L, et al. Microsatellite alterations in plasma DNA of small cell lung cancer patients[J]. Nat Med, 1996,2 (9) :1033.
  • 6Nawroz H, Koch W, Anker P, et al. Microsatellite alterations in serum DNA of head and neck cancer patients[J] Nat Med, 1996,2 (9): 1035.
  • 7Gahan P B, Anker P, Stroun M taneously released DNA? [ J]. Metabolic DNA as the origin of spon- Ann N Y Acad Sci,2008,1137(1) :7.
  • 8Schwarzenbach H, Alix-Panabiires C, Mtiller I, et al. Cell-free tumor DNA in blood plasma as a marker for circulating tumor ceils in pros- tate cancer[ J]. Clin Cancer Res ,2009,15 ( 3 ) : 1032.
  • 9Schwarzenbach H, Chun F K, Lange I, et al. Detection of tumor-spe- cific DNA in blood and bone marrow plasma from patients with pros- tate cancer[ J ] Int J Cancer,2007,120 (7) : 1465.
  • 10Hamilton T C, Smith A G, Griffin C A, et al. Ribonucleic acid in plas- ma from normal adults and multiple myeloma patients [ J ]. Clin Chem, 1979,25 (10) : 1774.

二级参考文献19

  • 1孔雁,姜达.循环肿瘤细胞的研究进展[J].中国肿瘤,2006,15(3):172-175. 被引量：9
  • 2Fiegl H, Millinger S, Mueller-Holzner E, et al. Circulating tumor-specific DNA :a marker for monitoring efficacy of adjuvant therapy in cancer patients [J]. Cancer Res, 2005,65 (4) :1141.
  • 3Chen X, Bonnefoi H, Diebold-Berger S, et al. Detecting tumor-related alterations in plasma or serum DNA of patients diagnosed with breast cancer[J]. Clin Cancer Res, 1999,5(9) :2297.
  • 4Wiedswang G, Borgen E, Schirmer C, et al. Comparison of the clinical significance of occult tumor cells in blood and bone marrow in breast cancer [J]. Int J Cancer, 2006, 118 (8) :2013.
  • 5Brown NM, Stenzel TF, Friedman PN, et al. Evaluation of expression based markers for the detection of breast cancer cells[J]. Breast Cancer Res Treat,2006,97(1) :41.
  • 6Cserni G,Bianchi S,Vezzosi V ,et al. The value of cytokeratin immunohistochemistry in the evaluation of axillary sentinel lymph nodes in patients with lobular breast carcinoma[J]. J Clin Pathol,2006,59(5):518.
  • 7Yamamoto F, Yamamoto M. Scanning copy number and gene expression on the 18q21-qter chromosomal region by the systematic multiplex PCR and reverse transcription-PCR methods [J]. Electrophoresis ,2007,28 ( 12 ) : 1882.
  • 8Savino M,Garrubba M, Parrella P, et al. Development of real-dine quantitative reverse transcription-PCR for Her2 detection in pel'ipheral blood from patients with breast cancer [J]. Clin Chim Acta,2007,384(1-2) :52.
  • 9van der Bruggen P, Traversari C, Chomez P, et al. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma [ J]. Science, 1991,254 ( 5038 ) : 1643.
  • 10van der Bruggen P, Traversari C, Chomez P, et al. A gene encoding an antigen recognized by cytolytie T lymphocytes on a human melanoma[J]. J Immunol. 2007, 178(5): 2617.

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实用癌症杂志
2012年 第6期

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