黄龙合剂治疗小儿咳嗽变异性哮喘的临床研究

Clinical study of Huanglong Mixture in treating infantile cough variant asthma

目的:观察黄龙合剂治疗小儿咳嗽变异性哮喘(风热夹痰证)的临床疗效。方法:选择咳嗽变异性哮喘(风热夹痰证)患儿70例,随机分为治疗组30例,中成药对照组和西药对照组各20例。治疗组予以黄龙合剂口服,中成药对照组予以麻甘颗粒口服,西药对照组予以孟鲁司特联合特布他林口服,3组疗程均为2周。结果:治疗组治愈7例(占23.3%),显效13例(占43.3%),有效8例(占26.7%),无效2例(占6.7%),总有效率93.3%;中成药对照组治愈2例(占10%),显效4例(占20%),有效6例(占30%),无效8例(占40%),总有效率60%;西药对照组治愈0例,显效1例(占5%),有效9例(占45%),无效10例(占50%),总有效率50%。3组总有效率比较,差异有高度统计意义(P<0.01)。结论:黄龙合剂治疗小儿咳嗽变异性哮喘疗效显著,值得临床推广应用。

Objective： To observe the clinical effect of Huanglong Mixture in treating infantile cough variant asthma （ wind-heat phlegm）. Methods ： 70 cases of cough variant asthma （ wind-heat phlegm syndrome） were ran- domly divided into treatment group with 30 cases, Chinese medicine group and western medicine group 20 cases each. The treatment group was orally given Huanglong Mixture, Chinese medicine group was orally given Magan Granule, and western medicine group was treated with Montelukast combined with Terbutaline orally, each group being treated for 2 weeks. Results： 7 cases in the treatment group were cured （23.3%）, 13 cases （43.3%） ob- vious effective, 8 cases （26.7%） effective, 2 cases{＆ 7% ） invalid, with the total efficiency of 93.3% ; 2 cases in Chinese medicine control group were cured （ 10% ）, 4 eases （ 20% ） obvious effect, 6 cases effective （ 30% ）, 8 cases （40%） invalid, the total effective rate being 60% ; 0 ease in the western medicine group were cured, 1 case （5% } obvious effect, 9 cases （45%） effective, 10 cases （50%） invalid, the total efficiency being 50%. The difference of total effective rate between the 3 groups has high statistical significance （ P〈0.01 ）. Conclusion： There is significant effect for Huanglong Mixture to treat infantile cough variant asthma, which is worth clinical pro- moted application.