pH值敏感型脂质体表面修饰技术的研究进展

Research progress in surface-modified technology of pH-sensitive liposomes

pH值敏感型脂质体表面修饰已成为脂质体制剂的研究热点,经过表面修饰的pH值敏感型脂质体进入人体后,在此特异性片段的介导下,被靶细胞识别,达到在靶细胞有针对性地释放药物和减少对机体正常组织损害的目的。对pH值敏感型脂质体进行表面修饰的主要目的有3个:延长体循环时间、增强pH值敏感性和提高靶向性。主要从这3方面综述近十年来pH值敏感型脂质体表面修饰的研究进展,为pH值敏感型脂质体表面修饰的进一步研究提供参考。

The surface-modified technology of pH-sensitive liposomes has become the hot topic in the research of liposomespreparation.The pH-sensitive liposomes after being surface-modified could be recognized by target cells in vivo mediated by thespecific segments so as to targetedly release the drugs and reduce the damage to human normal tissues.The surface-modifiedtechnology has three main purposes：prolonging drug in vivo circulation duration,increasing the pH-sensibility,and enhancing thetargeting.This paper reviews the recent ten-year progresses in the surface-modified technology of pH-sensitive liposomes on thesethree aspects,providing the reference for further study on the surface modification of pH-sensitive liposomes.