甘草酸对肾损伤的保护作用和临床应用研究进展

Advances in studies on protection and clinical application of glycyrrhizic acidin renal injury

动物实验研究证实甘草酸对缺血再灌注性、梗阻性、高血糖性、药物性(如马兜铃酸、庆大霉素、顺铂、阿霉素、镉等引起的)、变态反应性肾损伤都有保护作用。临床研究肯定了甘草酸在治疗肾综合征出血热中的疗效。已经有一些报道称甘草酸对慢性肾脏疾病、原发性干燥综合征并肾小管酸中毒、阿昔洛韦致急性肾衰竭和防治心脏手术引起的缺血再灌注性肾损伤也有疗效,但还需要其他研究在临床上进一步证实。

It has been proved that glycyrrhizic acid （GA） possesses renal protection against ischemia-reperfusion-,obstruction-,hyperglycemia-,drug （i.e.aristolochic acid,gentamycin,cisplatin,adriamycin or cadmium）-,and allergy-induced renal injury byanimal experiments.In clinical studies,the curative effect of GA on hemorrhagic fever with renal syndrome has been confirmed.GAhas efficacy in the treatment of chronic renal disease,primary sjogren syndrome with renal tubular acidosis,Acyclovir-induced renalfailure and renal ischemia-reperfusion injury after cardiac operation in some reports,but some further researches should be done inclinic in future.