麝香保心丸联合左卡尼汀治疗冠心病不稳定性心绞痛的疗效观察

Effective observation on Shexiang Baoxin Pills combined with levocarnitine in treatment of unstable angina

目的观察麝香保心丸联合左卡尼汀治疗冠状动脉粥样硬化性心脏病(冠心病)不稳定性心绞痛的临床疗效。方法将2007年1月至2012年6月收治的70例不稳定心绞痛患者随机分为硝酸甘油组(对照组,36例:硝酸甘油10 mg静脉泵入,每天1次,10 d为1个疗程)和麝香保心丸联合左卡尼汀组(治疗组,34例:在对照组治疗的基础上,给予麝香保心丸2粒,每天3次,口服,左卡尼汀3 g,静脉滴注,每天1次,10 d为1个疗程)。结果治疗组心绞痛症状改善总有效率为97.22%(35/36),对照组为82.35%(28/34),治疗组总有效率优于对照组,差异有统计学意义(P<0.05)。心电图改善总有效率:治疗组为91.67%(33/36),对照组为64.71%(22/34),治疗组总有效率优于对照组,差异有统计学意义(P<0.05)。结论麝香保心丸联合左卡尼汀对改善不稳定性心绞痛症状及心电图缺血的改变均优于硝酸甘油,并减少了心脏病事件的发生。

Objective To observe the clinical efficacy of Shexiang Baoxin Pill combined with levocarnitine in the treatment of coronary heart disease（CHD） unstable angina.Methods 70 cases of unstable angina in this hospital from January 2007 to June 2012 were randomly divided into 2 groups.The nitroglycerin group（control group,36 cases）was given nitroglycerin 10 mg by venous pump,once daily with 10 d as a course of treatment.The Shexiang Baoxin Pill combined levocarnitine group（treatment group,34 cases） was given oral Shexiang Baoxin Pill,3 times daily,2 pills each time,and levocarnitine 3 g by intravenous drip,once daily for 10 d as acourse of treatment.Results The total improvement rate of angina symptoms was 97.22% in the treatment group and 82.35% in the control group,the treatment group was better than the control group with statistical difference（P0.05）.The total improvement rate of electrocardiogram（ECG） was 91.67% in the treatment group and 64.71% in the control group,the treatment group was better than the control group with statistical difference（P0.05）.Conclusion Shexiang Baoxin Pill combined with levocarnitine is superior to nitroglycerin in improving the symptoms of unstable angina and the ischemic change of ECG and reduces the occurrence of cardiac events.