氯沙坦对肾小管损害保护作用的观察

Protection effect of losartan on damaged renal tubule

目的:研究氯沙坦对慢性肾脏病(CKD)患者肾小管损害的保护作用。方法:慢性肾脏病患者80例随机分为氯沙坦治疗组和对照组,比较两组肾小管损害标志蛋白(尿β2-微球蛋白和尿视黄醇结合蛋白)的变化。结果:治疗后氯沙坦治疗组尿中β2-微球蛋白和视黄醇结合蛋白明显减少,显著优于对照组(P<0.05)。结论:氯沙坦对慢性肾脏病患者的肾小管损害具有较好的保护作用。

Objective： To study the protection effects of losartan on renal tubule of patients with chronic kidney disease（CKD）.Methods： Eighty patients with CKD were randomly divided into losartan treatment group and control group,and changes of renal tubular damage marker proteins（urine beta 2-microglobulin and urine retinol binding protein） were compared between the two groups.Results：The urine-determination of beta 2-microglobulin and retinol binding protein significantly reduced in losartan treatment group,significantly higher than that of the control group（P0.05）.Conclusions： Losartan shows good protection effects on renal tubule of patients with CKD.