类风湿关节炎临床检验诊断性能评价

Evaluation of accuracy of rheumatoid arthritis clinical laboratory diagnostic performance

目的:类风湿关节炎患者IL-1RI、RFs、IL-lβ、CDK2等重点指标进行检测诊断性能评价。方法:以我院2011年8月～2012年8月收治的85例类风湿性关节炎确诊患者作为研究对象,其中活动期37例,缓解期48例。对活动期与缓解期患者进行指标比较,同时采用ELISA方法检测并比较活动期组患者与同期收治的同例数上呼吸道感染和健康体检患者IL-1RI、RFs、IL-lβ、CDK2等指标。结果:类风湿活动期与缓解期比较IL-1RI差异无统计学意义(P>0.05),两组CDK2差异对诊断有统计学意义,与上呼吸道感染和健康组比较IL-1RI、CDK2经秩和检验具有统计学意义(P<0.05)。结论:IL-1RI在类风湿临床诊断中具有重要作用,RFs是一项类风湿关节炎临床活动重要指标,可能与炎症严重程度有关,CDK2或可为治疗类风湿关节炎提供支持,由于例数较少,指标包含种类也不够完全,检测结果对于诊断类风湿性关节炎尚不够确切,还需进一步深入研究。

Objective： To evaluate the accuracy of diagnosing rheumatoid arthritis using IL-1RI,RFs,IL-lβ,CDK2 as indicators.Methods： A total of 85 patients confirmed as rheumatoid arthritis that were treated in our hospital from August 2011 to August 2012 were enrolled,of which,37 cases were in active stage stage,while 84 cases were in remission stage.Indicators including IL-1RI,RFs,IL-lβ,CDK2 of patients with active rheumatoid arthritis were detected and comparing with that of patients with upper respiratory tract infection and healthy volunteers using ELISA method.Results： No significant difference in IL-1RI was found between patients with remission stage of rheumatoid arthritis or active stage of the disease（P0.05）.But significant difference in CDK2 was found between the two groups.IL-1RI、CDK2 was significantly different between patients with upper respiratory tract infection and healthy volunteers（P0.05）.Conclusion： IL-1RI is an important indicator for the clinical diagnosis of rheumatoid arthritis,RFs can be important index indicating clinical activity of rheumatoid arthritis,which may be associated with inflammation severity.CDK2 is considered as supportive evidence for diagnosis of rheumatoid arthritis,but further study is needed.