高压氧、地塞米松治疗小儿化脓性脑膜炎疗效研究

Clinical effects of hyperbaric oxygen and dexamethasone in pediatric patients with suppurative meningitis

目的:探讨高压氧、地塞米松治疗小儿化脓性脑膜炎的临床疗效,为临床上治疗小儿化脓性脑膜炎提高指导。方法:入选2009年2月～2011年9月在我院住院治疗的化脓性脑膜炎患儿147例,根据患儿治疗过程中是否选择激素治疗将其分为治疗组(n=73)和对照组(n=74)比较两组患儿治疗结果。49例患儿选择高压氧治疗,分析其临床效果。结果:治疗后,采用地塞米松治疗组患儿结果优于对照组;49例患儿接受高压氧治疗后,均全部康复出院,无1例出现后遗症;而未接受高压氧治疗的98例患儿中3例(3.1﹪)出现耳聋、智力减退等后遗症,二者相比,x2=4.562,P<0.05。结论:辅助地塞米松治疗小儿化脓性脑膜炎可以提高临床疗效,而采用高压氧治疗则可以改善患儿预后。

Objective： To investigate the clinical effects of hyperbaric oxygen and dexamethasone in pediatric patients with suppurative meningitis.Methods： A total of 147 pediatric patients with suppurative meningitis that were treated in our hospital from February 2009 to September 2011 were enrolled and divided into treatment group（n=73） and control group（n=74）,the treatment group was given dexamethasone,while the control group was treated with hyperbaric oxygen,the clinical effect were analyzed.Results： The clinical effect of the treatment group was better than that of the control group.49 patients that underwent hyperbaric oxygen therapy all recovered,while 3 cases（3.1﹪） that was not given hyperbaric oxygen got deaf or hypophrenia showing significant difference between the two（χ2=4.562,P0.05）.Conclusion： Dexamethasone can improve the clinical therapeutic effects in pediatric patients with suppurative meningitis while hyperbaric oxygen can improve the prognosis.