期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

转基因动物及其在生物反应器中的应用与市场现状

下载PDF
导出
摘要 转基因动物是指用DNA重组技术将人们所需要的目的基因导入动物的受精卵或早期胚胎内，使外源目的基因随细胞的分裂而增殖并在体内表达，且能稳定地遗传给后代的动物。1982年美国华盛顿大学Palmiter等将大鼠生长激素基因导入小白鼠的受精卵里得到比正常体格大一倍的“超级小鼠”，此成果带动了转基因动物的一系列研究。
作者 许丽 李祯祺 王玥
机构地区 中国科学院上海生命科学信息中心
出处 《生物产业技术》 2012年第6期46-51,共6页 Biotechnology & Business
关键词 转基因动物 生物反应器 市场现状 DNA重组技术 应用 外源目的基因 基因导入 华盛顿大学
分类号 Q789 [生物学—分子生物学]
  • 相关文献

参考文献23

  • 1Palmiter R D, Brinster R L, Hammer R E, et al. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature, 1982, 300:611-615.
  • 2Krimpenfor: P, Radernakers A, Eyestone W, et al. Generation of transgenic dairy cattle using 'in vitro ' embryo production. Nature Biotechnology, 199l, 9(9): 844-847.
  • 3Wu X, Ouyang H, Duan B, et al. Production of cloned transgenie cow expressing omega-3 fatty acids. Transgenic Research, 2011:1-7.
  • 4Yang B, Wang J W, Tang B, el al. Characterization of bioactive recombinant human lysozyme expressed in milk of cloned transgenic carrie. PLoS One, 2011, 6(3): e17593.
  • 5Tessannc K, Golding M C, Long C R, ct al. Production of transgenic calves expressing an shRNA targeting myostatin. Molecular Reproduction and Development, 2012, 79(3): 176- 185.
  • 6Zhang Y L, Xi Q Y, et al. Production of Transgenie Pigs Mediated by Pseudotyped Lentivirus and Sperm. PLOS ONE, 2012, 7(4): e35335.
  • 7Hauschild J, Pctersen B, Santiago Y, et al. Efficient gcneratior: of abiaUelic knockout ig pigs using zinc-finger nucleases.PNAS, 2011, 108(29): 19013.
  • 8Min S, Qing S Q, et al. Generation of antiviral transgenie chicken using spermatogonial stem cell transfected in vivo. African Journal of Biotecbnology, 2011, 10(70): 15678-15683.
  • 9Kim B J, Kim K J, et al. Efficient enhancement of lentiviral transduction efficiency in murine spermatogonial stem cells. Molecules and Cells, 2012, 33(5): 449-455.
  • 10Gorden K, Lee E, Vitale J A, et al. Production of human tissue plasminogen activator in transgenic mouse milk. Biotechnology, 1992, 24: 425-428.

二级参考文献27

  • 1Wilmut I, Schnieke AE, McWhir J, et al. Viable offspring derived from fetal and adult mammalian cells. Nature, 1997, 385(6619):810- 813.
  • 2Schnieke AE, Kind A J, Ritchie WA, et al. Human factor Ⅸ transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science, 1997, 278(5346):2130-2133.
  • 3Donovan DM, Kerr DE, Wall RJ. Engineering disease resistant cattle. Transgenic Res, 2005, 14(5):563-567.
  • 4Lai L, Kang JX, Li R, et al. Generation of cloned transgenic pigs rich in omega-3 fatty acids. Nat Biotechnol, 2006, 24(4):435-436.
  • 5Kuroiwa Y, Kasinathan P, Sathiyaseelan T, et al. Antigen-specific human polyclonal antibodies from hyperimmunized cattle. Nat Biotechnol, 2009, 27(2):173-181.
  • 6Jaenisch R, Mintz B. Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA. Proc Natl Acad Sei U S A, 1974, 71(4): 1250-1254.
  • 7Salter DW, Smith El, Hughes SH, et al. Transgenic chickens: insertion of retroviral genes into the chicken germ line. Virology, 1987, 157(1):236-240.
  • 8Haskell RE, Bowen RA. Efficient production of transgenic cattle by retroviral infection of early embryos. Mol Reprod Dev, 1995, 40(3): 386-390.
  • 9Palmiter RD, Brinster RL, Hammer RE, et al. Dramatic growth of mice that develop from eggs microinjected with metallothioneingrowth hormone fusion genes. Nature, 1982, 300(5893):611-615.
  • 10Lavitrano M, Camaioni A, Fazio VM, et al. Sperm cells as vectors for introducing foreign DNA into eggs: genetic transformation of mice. Cell, 1989, 57(5):717-723.

共引文献11

生物产业技术
2012年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部