降阶梯疗法防治极低出生体重儿院内感染的临床观察

Clinical Observation on De-escalation Therapy in Preventing and Treating Very Low Birth Weight Infants with Nosocomial Infection

目的:探讨抗生素降阶梯疗法对极低出生体重儿院内感染的防治作用,降低患儿死亡率。方法:极低出生体重儿92例,随机分为试验组46例和对照组46例,对照组给予常规治疗,试验组在此基础上,加用抗生素降阶梯治疗,观察两组院内感染出现、控制及消失时间。结果:试验组感染控制时间、平均机械通气时间、住院时间、住院费用等均少于对照组,差异均有统计学意义(P<0.05)。结论:抗生素降阶梯疗法对极低出生体重儿院内感染的发生、发展有较好的防治作用,可减少机械通气机率,缩短住院时间,降低住院费用。

Objective：To investigate the antibiotic de-escalation therapy in very low birth weight infants with nosocomial infection prevention function,reduce the mortality of children.Methods：92 cases of very low birth weight infants,were randomly divided into the experimental group 46 cases and control group 46 cases,the control group was given routine treatment,experimental group on the basis of this,combined with antibiotic de-escalation therapy,observe two groups of nosocomial infection control and time appear,disappear.Results：The test group,the average time of infection control mechanical ventilation time,hospitalization time,hospitalization costs were lower than the control group,the difference was statistically significant（P0.05）.Conclusion：Antibiotic de-escalation therapy in very low birth weight infants hospital infection occurrence,development has good control effect,can reduce the mechanical ventilation rate,shorten the hospitalization time,reduce the cost of hospitalization.