口服西地那非治疗肺动脉高压的有效性及安全性

The Effectiveness and Safety of Oral Sildenafil Therapy in Pulmonary Arterial Hypertension

目的:探讨口服西地那非在治疗肺动脉高压上的有效性以及安全性。方法:选取2010年10月～2011年10月期间在本院治疗的肺动脉高压患者56例,对这56例患者采用口服西地那非进行治疗,对他们的临床治疗资料进行回顾性的分析。结果:治疗前平均肺动脉压力为(89.5±4.6)mmHg,治疗后平均肺动脉压力为(70.5±2.1)mmHg。治疗前后在肺动脉压力上具有显著性差异,(t=10.5262,P<0.05),有统计学意义;治疗前平均分钟的步行距离为(221.7±49.7)m,治疗后平均分钟的步行距离为(379.2±62.1)m。治疗前后在分钟的步行距离上具有显著性差异,(t=9.3529,P<0.05),有统计学意义;治疗时出现不良反应发生共3例,面部潮红1例,消化不良1例和肌肉疼痛1例,不良反应发生率10.71%,没有出现临床恶化的情况,没有发生严重的不良反应。结论:口服西地那非在治疗肺动脉高压上具有比较确切的临床疗效,安全性也比较高,值得临床推广使用。

Objective：To explore the effectiveness and safety of oral sildenafil therapy in pulmonary arterial hypertension（PAH）.Methods：To choose 56 cases of patients with PAH in our hospital between October 2010 to October 2011.The 56 cases took oral sildenafil treatment and their clinical treatment data was analyzed,retrospectively.Results：before treatment the mean PAH was（89.5±4.6） mmHg,and after treatment（70.5±2.1） mmHg.Obviously there＇s a significant difference（t= 10.5262,P0.05） before and after treatment with statistical significance.Before treatment the average minutes walking distance was（221.7±49.7）m,after treatment 379.2±62.1 m.There was a significant difference（t=9.3529,P0.05） in the minute walk distance before and after treatment,with statistical significance.It showed there were 3 cases with adverse reaction including 1 facial blushing,1 indigestion and 1 muscle pain,and the adverse reaction rate was 10.71%,in which there was no clinical deterioration situation and serious adverse reactions.Conclusion：oral sildenafil had the exact clinical efficacy and high safety in the treatment of pulmonary arterial hypertension,which was worthy of clinical use widely.