老年高血压患者动态血压与认知功能的关系

Relationship between ambulatory blood pressure and cognition function in the elderly patients with hypertension

目的探讨动态血压参数与老年高血压患者认知功能的关系。方法收集老年高血压患者60例进行24h动态血压监测及简易智能状态检查表(MMSE)行认知功能测定,根据MMSE得分分为对照组(n=35)和减退组(n=25),比较两组患者动态血压参数有无差异。结果对照组与减退组患者中24h平均收缩压[(127.38±19.14)mm Hg vs(132.00±15.09)mmHg]、白昼平均收缩压[(131.64±17.55)mm Hg vs(137.09±13.77)mm Hg]、夜间平均收缩压[(118.78±18.75)mm Hg vs(126.00±11.37mm Hg)]、昼夜节律比[(15.89±7.45)%vs(10.74±4.89)%]比较,差异有统计学意义(P<0.05);24h平均舒张压、白昼及夜间平均舒张压比较,差异无统计学意义(P>0.05)。结论收缩压、血压节律异常与老年高血压患者认知功能损害有关。

Objective To evaluate the relationship between ambulatory blood pressure and cognition function in the elderly hypertension patient.Methods 60 patients with essential hypertension underwent 24 h ambulatory blood pressure monitoring and MMSE determination of cognitive function,then were divided into two groups according to MMSE,control group（n=35） and cognitive dysfunction group（n=25）.To compared between the two groups difference in ambulatory blood pressure parameters.Results The two groups：SBP[（127.38±19.14）mm Hg vs（132.00 ±15.09）mm Hg],DSBP[（131.64±17.55）mm Hg vs（137.09 ±13.77）mm Hg],NSBP[（118.78±18.75）mm Hg vs（126.00 ±11.37 mm Hg）],Rate[（15.89±7.45）% vs（10.74±4.89）%]showed significant difference（P0.05）,but the result of DBP,DDBP,NDBP was not significantly different in two groups（P0.05）.Conclusion SBP and circadian rhythm have direct connection with cognition function in the elderly hypertension patient.