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Toll样受体信号传导通路及其在器官移植中作用的研究进展 被引量：1

Toll-Like Receptors Signaling and Research Progress of Its Role in Organ Transplantation
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摘要 目的了解Toll样受体(TLRs)信号传导通路及其在器官移植中的作用的研究进展。方法通过文献检索并总结TLRs及其配体结构、功能的特点,就近年来TLRs信号传导通路在动物实验和临床器官移植中的作用的研究进展进行综述。结果 TLRs在器官移植中发挥着重要作用,TLRs的活化可激活特异性免疫系统,使移植物发生缺血再灌注损伤、急性排斥反应和慢性排斥反应,同时也可通过TLRs诱导免疫耐受。早期治疗措施的干预可减少器官移植中移植物因缺血再灌注损伤所致的TLRs激活,从而提高移植物存活率;同时,针对TLRs及其介导的信号传导通路的相关免疫抑制靶点研发出的高效免疫抑制药物可减轻器官移植后缺血再灌注损伤和免疫排斥反应。结论 TLRs信号传导通路在缺血再灌注损伤、免疫排斥及免疫调节中起着重要作用。 Objective To review the research progress of Toll-like receptors（TLRs）signaling and its effects in organ transplantation.Methods The structural and functional features of TLRs and their ligands were summarized,the literatures in recent years about the research progress of TLRs signaling in animal experiment and clinical organ transplantation were reviewed.Results TRLs played an important role in the organ transplantation,the activation of TLRs could activate the specific immune system,and contribute to ischemic reperfusion injury,acute and chronic allograft rejections,and induce the immune tolerance.Early treatment intervention could reduce the activation of TRLs through ischemic reperfusion injury in the organ transplantation,and improve the allograft survival.The efficient immunosuppressive drugs which aimed at the related immunosuppressive target in immune and its signal transduction pathway could reduce ischemic reperfusion injury in the organ transplantation and immune rejection.Conclusions TRLs signaling plays an important role in ischemic reperfusion injury,immune rejection,and immune regulation.
作者 张黎 胡明道 陈鹏
机构地区 昆明医科大学第二附属医院肝胆胰一病区
出处 《中国普外基础与临床杂志》 CAS 2012年第11期1243-1248,共6页 Chinese Journal of Bases and Clinics In General Surgery
基金 国家自然科学基金项目(项目编号:81160069)~~
关键词 TOLL样受体 器官移植 缺血再灌注损伤 免疫排斥 Toll-like receptor Organ transplantation Ischemic reperfusion injury Immune rejection
分类号 R617 [医药卫生—外科学] R392.4 [医药卫生—免疫学]
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参考文献41

  • 1Medzhitov R, Prcston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [J]. Nature, 1997, 388(6640): 394-397.
  • 2Takeda K, Kaisho T, Akira S. Toll-like receptors [J]. Annu Rev Immunol, 2003, 21: 335-376.
  • 3Asprodites N, Zheng L, Geng D, et al. Engagement of toll-like receptor-2 on cytotoxic t-lymphocytes occurs in vivo and aug- ments antitumor activity [J]. FASEB J, 2008, 22(10): 3628- 3637.
  • 4Lorenz E. TLR2 and TLR4 expression during bacterial infec- tions [J]. CurrPharmDes, 2006, 12(32): 4185-4193.
  • 5Boehme KW, Guerrero M, Compton T. Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activa- tion in permissive cells [J]. J Immunol, 2006, 177(10): 7094- 7102.
  • 6Krasowska-Zoladek A, Banaszewska M, Kraszpulski M, et al. Kinetics of inflammatory response of astrocytes induced by TLR3 and TLR4 ligation [J]. J Neurosci Res, 2007, 85(1): 205-212.
  • 7Tabeta K, Georgel P, Janssen E, et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection [J]. Proc Natl Acad Sci USA, 2004, 101(10): 3516-3521.
  • 8Arbour NC, Lorenz E, Sehutte BC, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans [ J ]. Nat Genet, 2000, 25(2): 187-191.
  • 9Miyamoto Y, limura M, Kaper JB, et al. Role of Shiga toxin versus H7 flagellin in enterohaemorrhagic escherichia coli signa- ling of human colon epithelium in vivo [J]. Cell Microbiol, 2006, 8(5): 869-879.
  • 10GuanY, Ranoa DR, Jiang S, etal. Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signal- ing [J]. Jlmmunol, 2010, 184(9): 5094-5103.

二级参考文献27

  • 1Kawai T, Akira S. The role of pattern-recognition receptors in in- nate immunity: Update on Toll-like receptors [ J]. Nat Immunol, 2010, 11(5) : 373-384.
  • 2Clark GJ, Ju X, Hart DN, et al. The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions [ J]. Trends Immunol, 2009, 30(5): 209-217.
  • 3Kumagai H, Oki T, Kitamura T, et al. Identification and charac- terization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells [ J ]. Bioehem Biophys Res Commun, 2003, 307(3 ) : 719-729.
  • 4An H, Hou J, Zhou J, et al. Phosphatase SHP-1 promotes TLR-and RIG-Ⅰ-activated production of type Ⅰ interferon by inhibiting the kinase IRAKI [ J ]. Nat Immunol, 2008, 9 (5) : 542-550.
  • 5Yang P, An H, Liu X. et al. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta- catenin-dependent pathway [ J ]. Nat Immunol, 2010, 11 (6) : 487-494.
  • 6Abram CL, Lowell CA. Convergence of immunoreceptor and inte- grin signaling [ J ]. Immunol Rev, 2007, 218 (1): 29-44.
  • 7Roger T, Froidevaux C, Le Roy D, et al. Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4 [J]. Proc Natl Acad Sci U S A, 2009, 106(7) : 2348-2352.
  • 8Raby AC, Le Bouder E, Colmont C, et al. Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrup- ting TLR2 triggering [ J]. J Immunol, 2009, 183 (1): 506-517.
  • 9Coil RC, O'Neill LA. New insights into the regulation of signalling by toll-like receptors and nod-like receptors [ J]. J Innate Immun, 2010, 2(5) : 406-421.
  • 10Liu Y, Stewart KN, Bishop E, et al. Unique expression of sup- pressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo [ J ]. J Immunol, 2008, 180(9) : 6270-6278.

共引文献1

同被引文献31

  • 1Steward R,Mc Nally FJ,Schedl P.Isolation of the dorsal locus of Drosophila[J].Nature,1984,311(5983):262-265.
  • 2Modlin RL.Mammalian toll-like receptors[J].Ann Allergy Asthma Immunol,2002,88(6):543-548.
  • 3Takeda K,Kaisho T,Akira S.Toll-like receptors[J].Ann Allergy Asthma Immunol,2003,21(1):335-376.
  • 4Kawai T,Akira S.The role of pattern-recognition receptors in innate immunity:update on Toll-like receptors[J].Nat Immunol,2010,11(5):373-384.
  • 5Asprodites N,Zheng L,Geng D,et al.Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity[J].FASEB J,2008,22(10):3628-3637.
  • 6Jin MS,Lee JO.Structures of the toll-like receptor family and its ligand complexes[J].Immunity,2008,29(2):182-191.
  • 7Tsan MF,Gao B.Heat shock proteins and immune system[J].J Leukoc Biol,2009,85(6):905-910.
  • 8Guan Y,Ranoa DRE,Jiang S,et al.Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling[J].J Immunol,2010,184(9):5094-5103.
  • 9Beg AA.Endogenous ligands of Toll-like receptors:implications for regulating inflammatory and immune responses[J].Trends Immun,2002,23(11):509-512.
  • 10Akira S,Takeda K.Toll-like receptor signalling[J].Nat Rev Immunol,2004,4(7):499-511.

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中国普外基础与临床杂志
2012年 第11期

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