与戊型肝炎病毒感染相关的神经系统疾病研究进展

Review of hepatitis E virus infection-related neurological disorders

戊型肝炎病毒（HEV）感染是目前在发展中国家和发达国家引起急性肝炎的主要病原之一。根据核苷酸序列同源性分析,目前公认的HEV基因型有4个,分别为1、2、3和4型。此外,有人认为禽HEV为5型,鼠HEV为6型,但尚未得到公认。

Hepatitis E virus（HEV）infection is one of the common causes of acute hepatitis in both developing and developed countries.During the past few years,HEV has been found to be responsible for some chronic hepatitis in immunocompromised patients that can rapidly develop to cirrhosis.In addition,various HEV-related extrahepatic manifestations were reported as well.Recently,it has been suggested that HEV may be related to certain neurological symptoms or manifestations,such as Guillain-Barré syndrome,neuralgic amyo-trophy,acute transverse myelitis and etc.In this review,we summarize recently reported HEV infections with neurological manifestations and the clinical criterions for diagnosis.