驱白巴布期胶囊对SD大鼠抑郁模型的作用研究

Effects of Qubai Babuqi capsule on the depression model in SD rats

目的:探讨驱白巴布期胶囊对慢性应激导致的SD大鼠抑郁模型的作用。方法:通过旷场试验筛选合格SD大鼠60只,分为正常对照组、模型组、氟西汀组、驱白巴布期胶囊低、中、高剂量组,每组10只。正常对照组动物群养,正常饲养;造模动物孤养,接受不同的应激刺激3周。模型建立成功后,采用相应药物灌胃治疗9 d,采血,取血清,用ELISA试剂盒测4种神经肽的含量。结果:经过3周刺激后,与正常对照组相比,模型组大鼠的体质量及旷场试验动物活动次数明显降低,灌服药物后,中剂量组恢复效果较好。结论:中剂量组对精神刺激引起的大鼠抑郁有一定的调节作用,为驱白巴布期胶囊疗效的进一步研究做了铺垫作用。

OBJECtIVE To explore the effects of Qubai Babuqi capsule on chronic stress - induced depression model in SD rats. METHODS The qualified 60 SD rats were screened by open field test,and divided into normal group, model group, flu oxetine group, low, middle and high dose of Qubai Babuqi capsule groups（ 10 rats in each group）. The normal group rats were raised together, while the model animals raised lonely, and given different stress stimulator for 3 weeks. After the model suc cessfully made, they were treated i. g. of drugs for 9 days and then the serum was picked and taken out for measuring 5 neu ropeptide contents by ELISA kit. RESULTS After three weeks stimulation, compared with the normal group, the model rats ＇s body quality and the openfield test activity times reduced significantly. After taking medicaments, middle dose group of Qubai Babuqi capsule recovered better than the others. CONCLUSION The middle dose of Qubai Babuqi capsule has a invariable reg ulation effect on chronic stress-induced depression in SD rats;the present study is worthy for the further research of the effect on Qubai Babuqi capsule.