地诺前列酮栓与催产素、米索前列醇对促宫颈成熟及对分娩结局的影响

Comparison of effects of dinoprostone vaginal suppositories and misoprostol tablets and oxytocin on induced labor in postterm pregnant patients

目的:观察地诺前列酮栓(欣普贝生)与催产素、米索前列醇对促宫颈成熟的效果及对分娩结局的影响。方法:将273例过期妊娠患者分为欣普贝生组(简称观察组)、催产素组(对照1组)及米索前列醇组(对照2组),观察各组的促宫颈成熟及分娩结局。结果:观察组12 h内促宫颈成熟的有效率是90.11%,高于对照1组的78.02%和对照2组的80.22%,差异有显著性(χ2=4.16,P<0.05)。观察组不论是用药至临产时间,还是产程均低于对照1组和对照2组,差异有显著性(χ2=3.84,P<0.05;χ2=4.30,P<0.05);引产成功率则显著优于对照1组和对照2组,差异有极显著性(χ2=9.53,P<0.01)。分娩方式3组之间未见明显差异(χ2=1.02,P>0.05)。结论:欣普贝生可有效促宫颈成熟,引产效果较好,可减少不必要的剖宫产。

OBJECTIVE To compare the effects of dinoprostone vaginal suppositories and misoprostol tablets and oxytocin on cervical ripening and induced labor in postterm pregnant patients. METHODS 273 postterm pregnant women who requiredinduction of labor in our hospital were randomly divided inlo observalion group and control group 1 and control group 2. The cervical ripening and delivery outcome were observed. RESULTS The observation group 12 h cervical ripening efficiency was 90. 11 %, higher than the control group 1 and control group 2 （278. 02%.80. 22%）, the difference was significant （2 = 4. 16, P〈0. 05）. The observation group regardless of medication to time in labor, or labor were lower than those of control group 1 and control group 2, the difference was significant （X2 = 3.84, P〈0.05;）X2 = 4. 30, P〈0. 05） ; the success rate was significantly better than the control group 1 and control group 2, the difference has statistical significance （X2 = 9. 53,P〈0. 01）. The mode of delivery, between the three groups had no significant difference, （X2 = 1.02, P〉0. 05）. CONCLUSION Dinoprostone vagi hal suppositories is superior to oxytocin oncervical ripening and labor induction in postterm pregnancy. It ＇s safe and convenient.