两种非发酵菌的临床分布及耐药性分析

Distribution and drug resistance of clinically two non-fermentive Gram-negative bacili

目的:了解我院铜绿假单胞菌(PAE)和鲍曼不动杆菌(ABA)的临床分布和耐药性,为临床合理使用抗菌药提供依据。方法:对2009年1月—2011年12月分离到该两种非发酵菌的标本来源、分布科室以及药敏试验结果进行回顾性分析。结果:共检出PAE931株,ABA768株。其中PAE557株,占59.9%,ABA613株,占79.8%来自痰液;且主要集中在重症监护病房(PAE36%、ABA47.7%)和呼吸病房(PAE28.5%、ABA26.3%);PAE对阿米卡星、庆大霉素、妥布霉素、头孢哌酮/舒巴坦的耐药率小于10%,对头孢他啶的耐药率为15.9%,对其他三代头孢耐药率达40.1%～58.1%。ABA对头孢哌酮/舒巴坦耐药率小于10%,对其他抗菌药耐药率达23.7%～56.3%。结论:临床应根据药敏结果合理使用抗菌药物并加强对细菌耐药性的全面监测。

OBJECTIVE To analyze the distribution and resistance of Pesudomonas aeruginosa （PAE） and Acinetobacter baumannii （ABA）and to provide reference for rational use of antibiotics in the clinic. METHODS The results about the clinical isolation and the distribution of the specimen source of two non-fermentative bacteria and drug sensitivity test from Jan 2009 to Dec 2011 in hospital were retrospectively analyzed. RESULTS A total of 931 cases PAE and 768 cases of ABA were isolated. Source of specimens of the two non-fermenting bacteria isolated from sputum,included 557 cases PAE, accounting for 59. 9%, and 613 cases ABA, accounting 79. 8%. In the distribution of hospital departments, ICU was the most（PAE： 36.%;ABA： 46. 7%）,respiratory department was the second（PAE：28.5% ,ABA：26. 3%）. The results of drug resistance of PAE to AK, CN, TOB, SCF rate were less than 10% ;to CAZ the bacterial resistance was 15.9 %. To the other third-generation cephalospo tins,the bacterial resistance were 40. l%-58.1 %. The results of drug resistance of ABA to SCF was less than 10%, The re sults of drug resistance of other antibiotics was about 23.7%-56. 3%. CONCLUSION Clinical use of antimicrobial agents should be based on susceptibility results and strengthen the overall monitoring of bacterial resistance to antibiotics.