30%戊唑醇·甲基硫菌灵悬浮剂的研制

Formulation Preparation of Tebuconazole·Thiophanate-methyl 30% SC

【方法】通过正交优化法得到30％戊唑醇·甲基硫菌灵水悬浮剂的最佳配方。【结果】戊唑醇原药20％，甲基硫菌灵10％，D10024．5％，农乳33#2．5％，乙二醇5％，黄原胶0．25％，有机硅消泡剂0．3％，蒸馏水补足至100％。加工工艺研究发现：使用立式砂磨机，转速1400r／min，锆珠（d=1．2mm）最佳用量（即是制剂质量（埘）的1．9倍，最佳研磨时间为1．5h。【结论】得到的悬浮剂在pH值6．45—6．50条件下，（54±2）℃热贮14d，无析水、分层现象，分解率〈1％，倾倒性合格，产品各项指标符合悬浮剂的要求。

[Methods] Through the orthogonal optimization method, the formulation of tebuconazole, thiophanate- methyl 30% SC was obtained. [Results] The composition consisted of tebuconazole 20%, thiophanate-methyl 10%, D1002 4.5%, Nongru 33# 2.5%, ethanediol 5%, xanthan gum 0.25%, organic silicon defoamer 0.3%, the other component was distilled water. Vertical sanding machine was used to produce the formulation at 1400 r/min, the optimized milling time fixed on 1.5 h. Numerically, the volume of zirconium bead （d=1.2 mm） was 1.9 times of the quality of the preparation. [Conclusions] At the pH value of 6.45-6.50, the formulation had been stored at the temperature 54±2）℃ for 14 days, the decompositionratio was 〈1%, there were not precipitation and stratification, and it had good pourability, which conformed to the requirements for the formulation.