黏球菌189B05的次级代谢产物研究

Secondary Metabolites Produced by Myxococcus sp. 189B05

目的对黏球菌(Myxococcus sp.)189B05大罐发酵吸附树脂提取物的化学成分进行研究。方法采用Sephadex LH-20和硅胶等色谱柱色谱进行分离纯化,用波谱技术鉴定化合物的结构。结果从70 L发酵提取物中分离得到5个化合物,分别为quinolin-4-ylmethanol(1),myxothiazol(2),4-quinolinecarboxaldehyde oxime(3),N-(2-phenylethyl)acetamide(4),N-acetyltyra-mine(5)。结论化合物1～5均为首次从该菌株中分离得到。

OBJECTIVE To study the chemical constituents ofMyxococcus sp. 189B05 isolated from crop land soil sample col- lected in Shandong province. METHODS The constituents were isolated and purified by Sephadex LH -20 and silica columns and their structures were identified by NMR and ESIMS techniques. RESULTS Five compounds were isolated and identified as quinolin- 4-ylmethanol（ 1 ）, myxothiazol （2） ,4-quinolinecarboxaldehyde oxime （ 3 ）, N- （2-phenylethyl） acetamide （4）, N-acetyhyramine （ 5 ）, re- spectively. CONCLUSION Compounds 1 -5 were obtained from the strain for the first time.