益气护膜方对胃镜下黏膜切除或剥离术后黏膜修复的影响

Effects of Yiqi-Humo recipe on mucosa repair after EMR and ESD

目的观察益气护膜方对胃镜下黏膜切除术（endoscopicmucosalresction，EMR）或黏膜剥离术（endoscopicsubmucoaldissection，ESD）后患者黏膜修复的影响。方法将32例胃镜下EMR、ESD后患者按随机数字表法随机分为对照组14例采用奥美拉唑治疗，试验组18例在对照组治疗基础上加用益气护膜方治疗，两组患者均治疗4周为1个疗程，分别于术后第7天、第28天复查冒镜；观察并记录治疗前后患者的症状积分及胃黏膜征象积分。结果试验组于术后第28天在疼痛、泛酸、纳差、嘈杂方面[（0±0．00）分、（0±O．00）分、（2±0．11）分、（1±0．06）分]明显优于对照组同时期疗效[（12±0．86）分、（6±0．43）分、（15±1．07）分、（14±1．00）分，P〈O．01]，在改善黏膜充血、水肿方面[（3±0．17）分、（3±0．17）分]优于对照组[（16±1．14）分、（15±1．07）分，P均〈O．01]。结论益气护膜方可促进胃镜下EMR、ESD后黏膜修复。

Objective To observe the influences of Yiqi-Humo recipe, A traditional Chinese prescription, on mucosa repair after endoscopic mucosal resction （EMR） and （or） endoscopic submucoal dissection （ESD）. Methods 32 patients, who received EMR or ESD, were randomly recurited into a control group with 14 patients （omeprazole） and a experiment group with 18 patients （Yiqi-Humo recipe±omeprazole） Patients of both groups received treatment for a period of 4 weeks. Follow-up endoscopy was performed at 1 and 4 weeks after EMR or ESD, the index of symptom and mucosa signs were evaluated before and after the operation. Results At the 4 weeks after the procedure, the index of pain, pantothenic acid, anorexia, burning sensation in the experiment group [ （0±0.00）, （0±0.00）, （2±0.11）, （1 ±0.06） ] were lower than those in the control group [ （12±0.86）, （6± 0.43）, （15 ± 1.07）, （14±1.00）, P〈0.01]. The index of hyperemia and edema of the experiment group [ （3±0.17）, （3±0.17） ] were less than those of the control group[ （16±1.14）, （15 ± 1.07）, P〈 0.01]. Conclusion The prescription of Yiqi-Humo recipe promoted mucosa repair significantly after EMR or ESD.