老年2型糖尿病患者下肢血管病变的相关因素分析

Analysis of related risk factors of elderly T2DM patients with low-extremity arterial disease

目的探讨老年2型糖尿病患者下肢血管病变的相关因素。方法调查我院356例2型糖尿病患者，分析性别、年龄、糖尿病病程、血压、心率、血脂、身高、体质量、体重指数（BMI）、糖化血红蛋白（HbAlc）、空腹血糖（FBG）、餐后2h（2-hpp）血糖、空腹及2-hppC肽水平、空腹及2-hpp胰岛素水平、总胆固醇（TC）、三酰甘油（TG）、HDL、LDL、Plt水平与反映下肢血管病变的踝臂指数（ABI）的相关性。结果年龄、收缩压、HbAlc、2-hpp血糖水平与ABI呈负相关。2-hppC肽水平、2-hpp胰岛素水平与ABI呈正相关。而其他危险因素均与ABI无显著相关性。不同年龄层次的患者合并下肢血管病变的比例比较差异有统计学意义。结论年龄、收缩压、HbAlc、2-hpp血糖水平、2-hppC肽水平、2-hpp胰岛素水平与老年2型糖尿病患者下肢血管病变有关，其中年龄与其关系最为密切。

Objective To investigate the risk factors for lower extremity peripheral arterial disease （LEPAD） in elderly patients with Type 2 diabetes metlitus（T2DM）. Methods To detect ankle brachial index （ABI） of 356 elderly patients with T2DM, and analyze whether risk factors had correlation with ABI. Results We found that age, systolic blood pressure, HbAlc, 2-hours post-prandial （2hpp） plasma glucose had inverse correlation, yet 2hpp C-peptide plasma level, 2-hpp insulin level had positive correlation with ABI by bivariate correlation test. Conclusions Age, systolic blood pressure, 2hpp plasma glucose, 2hpp C-peptide plasma level, 2hpp insulin level were related with lower extremity arterial disease in the elderly with T2DM, among which age was the most important risk factor for LEPAD.