利培酮合并西酞普兰治疗强迫症的回访

Risperidone Combined with Citalopram in the Treatment of Obsessive-compulsive Disorder

目的观察利培酮合并西酞普兰治疗强迫症的疗效。方法将84例强迫症患者随机分为两组,观察组以利培酮合并西酞普兰治疗,对照组仅以西酞普兰治疗,疗程12周,病人出院后采用生活质量综合评定问卷(GQOLI-74)、家庭功能评定量表(FAD)进行回访。结果观察组GQOLI-74(除外物质生活维度)、FAD明显优于对照组(t=2.135,P<0.05)。结论利培酮合并西酞普兰治疗强迫症安全有效,患者出院后生活质量显著提高。

Objective To explore the efficacy of risperidone combined with citalopram in the treatment of obsessive-compulsive disorder.Methods A total of 84 patients with OCD were randomly equally divided into two groups,the observation group took risperidone combined with citalopram treatment,control group took citalopram only,treatment time was 12 weeks,patients were carried out a return visit with quality of life questionnaire（GQOLI-74）and family function rating scale（FAD）.Results The scores of GQOLI-74（except for the material life dimension）and FAD of observation group were significantly higher than those of control group（t=2.135,P0.05）.Conclusion Risperidone combined with citalopram is effective and safe in the treatment of obsessive-compulsive disorder,which can improve quality of life of patients after discharge.