溃愈散对溃疡性结肠炎患者血清IL-4水平的影响及疗效观察

Influence of Kuiyu Powder on Serum IL- 4 Levels in Patients with Ulcerative Colitis and Its Curative Effect

为观察溃愈散对溃疡性结肠炎（UC）患者血清IL-4水平的影响及临床疗效，将60例UC患者随机分为治疗组和对照组，每组30例。治疗组采用溃愈散保留灌肠治疗，对照组采用柳氮磺吡啶口服治疗。采用EI。ISA法检测两组患者治疗前后血清IL-4水平，并与30名健康志愿者（空白组）对照。结果显示，治疗组有效率为86．6％，对照组为70．0％，差异无统计学意义（P〉O．05）。两组肠黏膜病变疗效相当（P〉O．05）。治疗前两组血清IL-4水平差异无统计学意义，但均明显低于空白组（P〈O．01）；治疗后两组血清IL-4水平较治疗前均明显上升（P〈0．01），且治疗组上升程度高于对照组（P〈O．01）。两组不良反应的发生率，治疗组较对照组明显减少（6．7％VS20．0％，P〈O．05）。结果表明，溃愈散对UC有良好的治疗作用，并可提高uC患者血清IL-4水平。

In order to observe the influence of Kuiyu powder on serum II74 levels in patients with ulcera- tive colitis（UC） and its clinical effect, 60 cases were randomly divided into treatment group and control group,30 cases for each. Kuiyu powder was given to treatment group by retention enema, while sul- fasalazine to control group orally. Both groups were determined for serum IL-4 levels with ELISA before and after treatment and compared with 30 healthy subjects （blank group） afterwards. The results showed that the effective rate was 86.60//00 in treatment group and 70.0% in control group,which showed no statis- tical differences（ P 〉0.05） ;the clinical efficacy for pathological changes of intestinal mucosa was similar in hoth groups（ P 〉 0.05）. Before treatment serum IL-4 levels showed no statistical differences in both groups,but were significantly lower than those in blank group（ P 〈0.01）. Serum IL-4 levels all increased significantly in both groups after treatment,and more significantly in treatment group （ P 〈0.01）. Treat- ment group had a lower incidence of adverse reaction than the control group（6.7~ vs 20.0~, P 〈0.05）. It is concluded that Kuiyu powder has a better effect on UC and can increase IL- 4 levels in the serum.