早期肠内外营养联合应用在结肠癌术后的效果观察

Observation on the Efficacy of Early Combined Enteral and Parenteral Nutrition for Colon Cancer after Sur- gery

为观察结肠癌术后患者早期肠内外联合营养支持的临床效果与安全性，将60例结肠癌术后患者随机分为肠内营养（EN）与肠外营养（PN）联合组（EN十PN组）和全肠外营养组（TPN组），每组30例。结果显示，EN＋PN组的肛门排气时间、肛门排便时间和术后住院时间均显著短于TPN组（P〈0．05）。两组术后1周的体质量、总蛋白及白蛋白均较术前降低，而前白蛋白较术前升高（P〈0．05），但EN＋PN组明显高于TPN组（P〈0．05），两组血红蛋白手术前后及组间比较均无统计学意义（P〉0．05）。EN＋PN组的并发症发生率为10．0％，明显低于TPN组的26．7％（P〈O．05）。结果表明，结肠癌患者术后早期采用EN＋PN联合营养支持，作用显著，可作为结肠癌术后最佳的营养支持方式。

In order to observe the clinical efficacy and safety of early combined enteral nutrition（EN） and parenteral nutrition（PN） in supporting postoperative patients with colon cancer, 60 cases were randomly divided into combination group（EN ＋PN） and total parenteral nutrition（TPN） group, 30 cases for each. The results showed that time for flatus, bowel movement and postoperative hospital stay in combination group was significantly shorter than that in TPN group （ P〈0.05）. The level of body weight,total protein and albumin dropped significantly 1 week after surgery; however,the level of prealbumin increased signifi- cantly（ P 〈0.05） ,in which combination group was significantly higher than TPN group （ P %0.05）. No significant difference was found in hemoglobin of two groups between before and after surgery（ P ~0.05）. The incidence of complications was 10.0% in combination group,which was obviously lower than that in TPN group（26.7 %, P 〈0.05）. It is concluded that early combined enteral and parenteral nutrition plays a significant role in supporting postoperative patients with colon cancer and serves as the best way of nutri- tional support.