美沙拉秦栓治疗溃疡性结肠炎56例临床疗效观察

Mesalazine Suppository for Ulcerative Colitis：Clinical Effect Observation of 56 Cases

为观察美沙拉秦栓治疗溃疡性结肠炎（uc!的临床疗效，选择112例轻、中度UC患者，随机分为两组，治疗组56例采用美沙拉秦栓纳肛，1枚／次，1次／d；对照组56例采用口服柳氮磺吡啶片1．Og／次，4次／d。两组疗程均为8周。结果显示，美沙拉秦栓纳肛治疗UC比口服柳氮磺吡啶片效果明显（92．9％VS67．9％，P〈O．05），治疗组治疗过程中不良反应的发生率明显低于对照组（10．7％VS57．1％，P〈O．05）。结果表明，美沙拉秦栓纳肛治疗轻、中度UC临床疗效优于口服柳氮磺吡啶片，且不良反应少。

This study was to observe the clinical efficacy of mesalamine suppository for ulcerative colitis （UC）, 112 cases with mild and moderate UC were randomly divided into treatment group and control group,56 cases for each. Mesalazine suppository was used into anus to treatment group, 1 suppository/ time, 1 time/d and oral sulfasalazine to control group in a dose of 1.0g,four times daily. Both groups were all treated for 8 weeks. The results showed that mesalazine suppository administered anally was more effec- tive than oral sulfasalazine for UC（92.9% vs 67.9%, P 〈0.05） ,the incidence of adverse reactions admin- istered anally was significantly lower in treatment group than that in control group（10.7% vs 57.1%, P 〈 0.05）. It is concluded that mesalazine suppository administered anally is more effective than oral sul- fasalazine for mild and moderate UC and has fewer adverse reactions.