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Biocompatibility Evaluation of Polyethylene Terephthalate Artificial Ligament Coating Hydroxyapatite by Fibroblasts Cells in Vitro

Biocompatibility Evaluation of Polyethylene Terephthalate Artificial Ligament Coating Hydroxyapatite by Fibroblasts Cells in Vitro
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摘要 Hydroxyapatite(HA) based materials have been widely used in the field of ligament tissue engineering in the past decades.It has been previously reported that HA can increase the penetration of marrow-derived mesenchymal stem cells(MSCs) and MSCs cells into scaffolds due to increased cell differentiation in biological media.Additionally,it was found that there are much difference between MSCs and anterior cruciate ligament (ACL) cells.For that reason,we mainly evaluate the biocompatibility of polyethylene terephthalate(PET) silk scaffold with fibroblasts cells in vitro.We cultured mouse fibroblasts cells on the substrate of PET fiber and PET-HA scaffold,respectively,and then observed the morphology by using scanning electron microscopy.Our data indicate that PET-HA scaffold has good biocompatibility with fibroblasts cells and can potentially be useful in enhancing the fibroblasts cell differentiation and proliferation. Hydroxyapatite （HA） based materials have been widely used in the field of ligament tissue engineering in the past decades. It has been previously reported that HA can increase the penetration of marrow-derived mesenchymal stem cells （MSCs） and MSCs cells into scaffolds due to increased cell differentiation in biological media. Additionally, it was found that there are much difference between MSCs and anterior cruciate ligament （ACL） cells. For that reason, we mainly evaluate the biocompatibility of polyethylene terephthalate （PET） silk scaffold with fibroblasts cells in vitro. We cultured mouse fibroblasts cells on the substrate of PET fiber and PET-HA scaffold, respectively, and then observed the morphology by using scanning electron microscopy. Our data indicate that PET-HA scaffold has good biocompatibility with fibroblasts cells and can potentially be useful in enhancing the fibroblasts cell differentiation and proliferation.
作者 蒋佳 郝威 李毓卓 陈俊 姚晋荣 邵正中 李宏 杨建军 陈世益
机构地区 Sports Medicine Center Laboratory of Advanced Materials Department of Bio-Nano Science and Engineering
出处 《Journal of Shanghai Jiaotong university(Science)》 EI 2012年第6期717-722,共6页 上海交通大学学报（英文版）
基金 the Young Project of National Natural Science Foundation of China(No.81000816) the National Basic Research Program(973) of China (No.2009CB930000) the Project of Shanghai Municipal Science and Technology Commission (No.11JC1401700)
关键词 聚对苯二甲酸乙二醇酯 成纤维细胞 生物相容性 羟基磷灰石 韧带 骨髓间充质干细胞 评价 体外 artificial ligament, ligamentization, hydroxyapatite, fibroblasts cells, biocompatibility
分类号 TQ323.41 [化学工程—合成树脂塑料工业] Q516 [生物学—生物化学]
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参考文献21

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Journal of Shanghai Jiaotong university(Science)
2012年 第6期

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