面包海星中一个新的化合物面包海星皂苷G

Novaeguineside G,A New Aasterosaponine from the Starfish Culcita novaeguineae

目的:研究面包海星中的海星皂苷活性成分。方法:以稻瘟霉活性筛选模型追踪指导,采用多种现代层析方法和波谱技术,对海星皂苷活性成分进行追踪提取分离和结构鉴定。结果:分离得到一个面包海星皂苷类化合物,并应用2D-NMR、ESI-MS技术和化学方法鉴定其结构为:sodium(20R,22R,23S,24S)-6α-O-{β-D-fucopyrano-syl-(1→2)-β-D-quinovopyranosyl-(1→4)-[β-D-quinovopyranosyl-(1→2)]-β-D-quinovopyranosyl-(1→3)-β-D-glucopyr-anosyl}-22,23-epoxy-20-hydroxy-24-methyl-5α-cholest-9(11)-en-3β-yl-sulfate。结论:该化合物为新化合物,命名为面包海星皂苷G。

Objective： To study the bioactive asterosaponin from the starfish Culcita novaeguineae. Methods： Guided by Pyricularia oryzae bioassay method with a combination of multi-chromatographies, the bioactive asterosaponins were separated from the srarfish Cul- cita ruyvaeguineae. Results： A asterosaponin was obtained and identified by chemical methods and spectral analyses especially ESI-MS and 2D-NMR techniques, its structure was elucidated as ： sodium （ 20R, 22R, 23S, 24S） -6a-O- {β-D- fucopyranosyl- （ 1-2 ） -β-D-quino- vopyranosyl-（1-4）-[β-D-quinovopyranosyl-（1-2） ] -β-D-quinovopyranosyl-（1-3）-β-D-glucopyranosyl1-22,23-epoxy-20-hydroxy- 24-methyl-5a-cholest-9（ 11 ）-en-3β-yl-sulfate. Conclusion： The compound is a new asterosaponin,named as novaeguineside G.