黄连的化学成分研究

Chemical Constituents from Coptis chinensis

目的:研究毛茛科植物黄连Coptis chinensis Franch.的化学成分。方法:利用柱色谱、凝胶柱色谱、高效液相色谱等分离技术对黄连的95%乙醇提取物进行分离,根据其所得化合物的理化性质与UV、IR、MS、NMR等光谱数据鉴定其结构。结果:从黄连的95%乙醇提取物的氯仿萃取部分分离得到7个成分,分别鉴定为甲基小檗碱(1)、8,9-dihydroxy-1,5,6,10b-tetrahydro-2H-pyrrolo[2,1-α]isoquinolin-3-one(2)、(±)5,5'-二甲氧基落叶松脂醇(3)、3,4-二羟基苯乙醇(4)、methyl-5-O-feruloylquinate(5)、ethyl-5-O-feruloylquinate(6)和apocynol(7)。结论:其中化合物3为首次从该属植物中分离得到,化合物5～7为首次从该植物中分离得到。

Objective： To study the chemical constituents of Coptis chinensis. Methods： The compounds were separated and puri- fied by column chromatography and their structures were identified by spectroscopic methods. Results：Seven compounds were isolated from the chloroform extract of Coptis chinensis, whose structures were determined as worenine （1）, 8,9-dihydroxy-1,5,6, 10b-tetra- hydro-2 H-pyrrolo [ 2,1 -a ] isoquinoliu-3 -one （ 2 ）, （ ± ） -5,5 ＇-dimethoxy-larieiresinol （ 3 ）, 3,4-dihydroxy-phenylethylalcohol （ 4 ）, meth- yl-5-O-feruloylquinate （ 5 ）, ethyl-5-O- feruloylquinate （6）, apocynol （ 7 ）. Conclusion ： Compounds （ 3 ） is isolated from this genus for the first time, compounds （ 5 ）, （ 6 ）, （ 7 ） are isolated from this plant for the first time.