β-榄香烯长循环脂质体药物动力学研究

The Pharmacokinetics of Long-circulating β-elemene Liposomes

目的:研究β-榄香烯长循环脂质体药物动力学。方法:建立气相色谱法测定小鼠注射β-榄香烯长循环脂质血浆中β-榄香烯的含量。结果:β-榄香烯长循环脂质体的α、T1/2β、K12和AUC高于普通脂质体,而T1/2α、Vc、CL、K10则低于普通脂质体。结论:表明β-榄香烯循环脂质体可以延长β-榄香烯在体内的作用时间,更好地提高其临床疗效。

Objective ： To study the pharmacokinetics of long-circulating β-elemene liposomes. Methods ： Gas chromatography was established to determine the concentration of β-elemene in plasma of rats. Results：The a,T1/2β, K12 and AUC of long-circulating β-elemene liposomes groups were higher compared with those of the conventional liposomes, and the T1/2a, Vc, CL, K10 of the latter were lower. Conclusion：Long-circulating β-elemene liposomes can prolong the duration of β-elemene in the body and improve the efficacy of drugs.