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头颈部肿瘤与血管内皮生长因子关系的研究进展 被引量：2

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摘要 恶性肿瘤的生长和侵袭转移与肿瘤血管的生成密切相关。当肿瘤体积〉2mm3后,局部缺血缺氧,需要产生新的毛细血管以维持肿瘤的生长,肿瘤细胞亦经新生血管发生血行转移。肿瘤血管生成是一个多因素调节的复杂过程,主要取决于血管生成促进因子和抑制因子的严密调节。
作者 崔彩霞 戚乐
机构地区 杭州师范大学附属医院耳鼻咽喉科 杭州师范大学附属医院放射科
出处 《上海医学》 CAS CSCD 北大核心 2012年第10期904-908,共5页 Shanghai Medical Journal
基金 浙江省医药卫生一般研究计划(2011KYB068) 浙江省医学会临床科研基金(2011ZYC-A33) 杭州市卫生科技计划一般(A)类项目(2011A018)资助
关键词 血管内皮生长因子 头颈部肿瘤 肿瘤血管生成 新生血管发生 侵袭转移 恶性肿瘤 肿瘤体积 缺血缺氧
分类号 R739.91 [医药卫生—肿瘤]
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参考文献26

  • 1ROSKOSKI R Jr. Vascular endothelial growth factor (VEGF) signaling in tumor progression[J].Critical Reviews in Oncology/Hematology,2007,(03):179-213.
  • 2KARATHANASIS E,CHAN L,KARUMBAIAH L. Tumor vascular permeability to a nanoprobe correlates to tumor-specific expression levels of angiogenic markers[J].PLoS One,2009,(06):e5843.
  • 3YANCOPOULOS G D,DAVIS S,GALE N W. Vascular-specific growth factors and blood vessel formation[J].Nature,2000,(6801):242-248.
  • 4DA M X,WU X T,WANG J. Expression of cyclooxygenase-2 and vascular endothelial growth factor-C correlates with lymphangiogenesis and lymphatic invasion in human gastriccancer[J].Archives of Medical Research,2008,(01):92-99.doi:10.1016/j.arcmed.2007.06.021.
  • 5KESKITALO S,TAMMELA T,LYYTIKKA J. Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein[J].Circulation Research,2007,(10):1460-1467.
  • 6KO Y H,JUNG C K,LEE M A. Clinical significance of vascular endothelial growth factors (VEGF) C and-D in resected non-small cell lung cancer[J].Cancer Res Treat,2008,(03):133-140.
  • 7BESIG S,VOLAND P,BAUR D M. Vascular endothelial growth factors,angiogenesis,and survival in human ileal enterochromaffin cell carcinoids[J].Neuroendocrinology,2009,(04):402-415.
  • 8TSUTSUI S,MATSUYAMA A,YAMAMOTO M. The Akt expression correlates with the VEGF-A and-C expression as well as the microvessel and lymphatic vessel density in breast cancer[J].Oncology Reports,2010,(03):621-630.
  • 9TSE G M,CHAN A W,YU K H. Strong immunohistochemical expression of vascular endothelial growth factor predicts overall survival in head and neck squamous cell carcinoma[J].Annals of Surgical Oncology,2007,(12):3558-3565.doi:10.1245/s10434-007-9632-0.
  • 10O-CHAROENRAT P,RHYS-EVANS P,ECCLES S A. Expression of vascular endothelial growth factor family members in head and neck squamous cell carcinoma correlates with lymph nodemetastasis[J].Cancer,2001,(03):556-568.

二级参考文献37

  • 1Jun Hui Cui~1 Uwe Krueger~2 Doris Henne-Bruns~2 Bemd Kremer~2 Holger Kalthoff~2 ~1Department of General Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China ~2Department of General Surgery,Christian-Albrechts-University,Kiel,GermanyDr.Jun Hui Cui graduated from Zhejiang Medical University in 1984,earned master degree in 1990,studied in the Surgical Department of Kiel University and worked in the Lab of Molecular Oncology of Kiel University from 1994-1997achieved M.D.from Kiel University.Germany,now associate professor of surgery,specialized in colorectal oncology.Adviser of graduated student for master degree,having 20 publications published in key Chinese or English journals..Orthotopic transplantation model of human gastrointestinal cancer and detection of micrometastases[J].World Journal of Gastroenterology,2001,7(3):381-386. 被引量：19
  • 2高随宽,刘占兵,杨尹默,赵建勋,汪欣,刘玉村,万远廉,徐文怀.COX-2与VEGF-C在直肠癌中的表达及其在淋巴转移中的意义[J].中华普通外科杂志,2006,21(4):269-271. 被引量：8
  • 3Weidner N,Semple JP,Welch WR,et al. Tumor angiogenesis and matastasis-correlation in invasive breast carcinoma. N Engl J Med, 1991,324(1):1-8.
  • 4Ribatti D. Transgenic mouse models of angiogenesis and lymphangiogenesis. Int Rev Cell Mol Biol, 2008,266:1-35.
  • 5Ruggefi B, singh J, Gingrich D, et al. CEP-7055 : a novally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical model. Cancer Res, 2003,63 : 5978-5991.
  • 6Dvorak HF. How tumors make bad blood vessels and stroma. Am J Pathol,2003,162(6): 1747-1757.
  • 7Shibuya M. Differential roles of vascular endothelial growth factor reeeptor-I and receptor-2 in angiogenesis. J Biochem Mol Biol, 2006,39: 469--478.
  • 8Takahashi H,Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond),2005,109(3):227- 241.
  • 9Dai J, Rabie AB. VEGF: an essential mediator of both angiogenesis and endocbondral ossification. J Dent Res, 2007,86(10):937- 950.
  • 10Shibuya M,Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res, 2006,312(5):549-560.

共引文献24

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上海医学
2012年 第10期

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