原发性高血压病患者血同型半胱氨酸与尿微量蛋白关系研究

Relationship between serum homocysteine and urinary albumin in patients with essential hypertension

目的研究原发性高血压患者血同型半胱氨酸与尿微量蛋白之间的关系。方法将2010年7月至2011年12月期间在河南省人民医院住院的原发性高血压病患者（266例），按照血同型半胱氨酸（Hcy）水平的不同分为三组：A组88例（血Hcy〈15．0μmol／L），B组102例（15μmol／L≤Hcy〈20．0μmoL／L，），C组76例（≥20μm01）／L，分别测定并比较三组患者的尿微量蛋白，探究血同型半胱氨酸与尿微量蛋白的关系。结果三组高血压病患者，随着同型半胱氨酸水平的升高，尿微量蛋白亦升高，A组〈B组〈C组，组间比较差异有统计学意义（P〈0．05）。结论原发性高血压病患者血同型半胱氨酸与尿微量白蛋白之间具有相关性。

Objective To investigate the relationship between serum homocysteine（Hcy）and urinary albumin in patients with essential hypertension. Methods The 266 essential hypertensive patients with essential hypertensive recruited were treated between July 2007 and December 2011 in henan provincial people＇s hospital. They were divided into three groups according to serum homcoysteine： group A （Hcy 〈 15.0 μmo]/L）, group B （15 μmol/L≤Hcy 〈20. 0 μmoL/L）, group C（ 320 μmol/L）. To deterrain and compare the urinary albumin of the three groups and to explore the relationship between both. Results The difference was significant, urinary albumin level： group A 〈 group 13 〈 group C （P 〈 0. 05）. The higher the homoeysteine level was, the higher the UAlb was. Conclusions In patients with essential hypertensive, UAlb is positively correlated with Hey.