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白细胞介素-16基因多态性与肝癌遗传易感性的研究 被引量：4

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摘要 目的:探讨白细胞介素-16(IL-16)基因rs11556218T/G、rs4072111C/T、rs4778889T/C3个位点的多态性与肝癌(HCC)易感性的关系。方法:采用聚合酶链反应限制性片段长度多态性(PCR-RFLP)方法检测141例HCC患者(HCC组)与142例健康个体(对照组)的IL-16基因的3个位点的基因型分布及差异。结果:rs11556218T/G和rs4072111C/T两个位点的基因型分布在HCC组和对照组人群中差异无统计学意义(P>0.05)。rs4778889T/C位点的TC基因型在HCC组中的频率显著低于对照组(P<0.05),与TT基因型相比,TC基因型患HCC风险显著降低至0.50倍。GTC单倍型在HCC组和对照组中的分布频率有差异(P<0.05)。结论:IL-16rs4778889T/C位点的基因多态性与肝癌的遗传易感性有关。
作者 邓燕 李若林 黄霞梅 陈志坚 黄珊 李山 秦雪
机构地区 广西医科大学第一附属医院检验科 广西医科大学第一附属医院科研部
出处 《实用医学杂志》 CAS 北大核心 2012年第23期3910-3912,共3页 The Journal of Practical Medicine
基金 广西卫生厅资助项目(编号:桂卫Z2010373 桂卫Z2011356 桂卫Z2011357)
关键词 肝肿瘤 IL-16 单倍型
分类号 R735.7 [医药卫生—肿瘤]
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参考文献14

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同被引文献49

  • 1姜凤元,陈晓泉.肝细胞癌组织C-met的表达与临床意义[J].陕西医学杂志,2007,36(3):307-309. 被引量：2
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  • 3Azimzadeh P,Romani S,Mohebbi SR,et al. Interleukin-16 (IL-16) genepolymorphisms in Iranian patients with colorectal cancer( J]. J Gastroint-est Liver Dis,2011 ;20(4) :371-6.
  • 4Gao LB,Liang WB,Xue H,ef al. Genetic polymorphism of interleukin-16and risk of nasopharyngeal carcinoma[ J]. Clin Chim Acta,2009;409(1-2):132-5.
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  • 6Li S, Deng Y, Chen ZP ,et al. Genetic polymorphism of interleukin-16 in-fluences susceptibility to HBV-related hepatocellular carcinoma in a Chi-nese population[ J]. Infect Genet Evol,2011 ;ll(8) :2083-8.
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  • 10YellapaA,Bitterman P,Sharma S,et al.Interleukin 16 expressionchanges in association with ovarian malignant transformation[J],Am J Obstet Gynecol,2014,210(3):272 e271-272 e210.

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实用医学杂志
2012年 第23期

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