血清Hcy、FA和VitB_(12)检测的临床回顾性分析

The Retrospective Analysis of the Clinical Significance of Serum Homocysteine,FA and Vit B_(12)

目的:探讨了血清同型半胱氨酸(Hcy)检测的临床意义。方法:应用化学发光法和放射免疫分析对155例心脑血管病、糖尿病、消化道恶性肿瘤患者进行了血清Hcy和FA、VitB12检测,并与35名正常健康人作比较。结果:心脑血管病、糖尿病、消化道恶性肿瘤患者血清Hcy水平非常显著地高于正常人组(P<0.01),且血清FA、VitB12水平呈显著地低于正常人组(P<0.01)。血清Hcy是动脉硬化性心脑血管病及糖尿病、消化道恶性肿瘤的危险因子。且血清Hcy水平与FA、VitB12水平呈显著负相关(r=-0.4511、-0.5134,P<0.01)。结论:FA、VitB12补充疗法可降低血清Hcy,有可能成为动脉硬化性心脑血管病及糖尿病、消化道恶性肿瘤高Hcy血症的治疗方案。

Objective To explore the clinical significance of serum homocysteine,FA and VitB12. Methods Serum Hcy（with CLIA）, serum FA, VitB12 （wlth RIA） levels were measured in 155 patients with cardiovascular-cerebral diseases, diabetes and malignant tumors of digestive system as well as 35 normal controls were studied respectively. Results The serum homocysteine level in patients with diseases, diabetes and malignant tumors of digestive system was significantly higher than that in controls（P 〈 0.01 ）. But serum FA, VitBt2 levels were markedly lower （P 〈 0. 01 ）. Serum Hcy level was negative correlated with FA, VitB12 levels （r = -0.4511, -0.5134 ,P 〈 0.01 ）. The serum homocysteine level is a risk factor of atheromatous cardiovascular-cerebral disease,diabetes and malignant tumor of digestive system. Conclusion The treatment with FA, VitB,2 could reduce the serum level of homocysteine. This might be a therapeutic way for hyperhomocystinemia in patients with atheromatous cardiovascular cerebral disease, diabetes and malignant tumor of digestive system.