摘要
目的:探讨了冠心病(CHD)患者血浆ET-1、颗粒膜蛋白-140(GMP-140)和血清妊娠相关蛋白A(PAPP-A)水平的变化及临床意义。方法:应用放射免疫分析和化学发光法对98例CHD患者进行了血浆ET-1、GMP-140和PAPP-A水平的测定,其中稳定性心绞痛(SAP)38例,不稳定性心绞痛(UAP)32例。急性心肌梗死(AMI)28例,并与35名正常人作比较。结果:CHD患者血浆ET-1、GMP-140和血清PAPP-A水平均显著地高于正常人组(P<0.01),AMI和UAP组又高于SAP组(P<0.05),且血清PAPP-A水平与ET-1、GMP-140水平呈正相关(r=0.6184、0.5762,P<0.01)。结论:检测CHD患者血浆ET-1、GMP-140和血清PAPP-A水平的变化对CHD的发生和发展以及疗效和预后观察均具有重要的临床意义。
Objective To explore the clinical significance of determination the changes of plasma ET-1,GMP-140 and serum PAPP-A levels in patients with coronary heart disease（CHD）.Methods Plasma ET-1,GMP-140（with RIA） and serum PAPP-A（with electrochemiluminesence） levels were determined in patients with CHD（38 SAP,32UAP,28 AMI） and 35 normal healthy individualls served as control group.Results Plasma ET-1,GMP-140 and serum PAPP-A levels in patients with CHD were distinctly higher than those in controls（P0.01）.Among the CHD patients magnitude of changes of the levels of plasma ET-1,GMP-140 and serum PAPP-A in AMI and UAP groups were significantly higher than those in SAP groups（P0.05）.Serum PAPP-A level was positively correlated with plasma ET-1,GMP-140 levels（r=0.6184,0.5762,P0.01）.Conclusion The changes of plasma ET-1,GMP-140 and serum PAPP-A levels were closely related to the genesis and development,also can be applied monitoring therapeutic efficacy and predicting prognosis,therefore provides important clinical significance of CHD.
出处
《放射免疫学杂志》
CAS
2012年第6期619-621,共3页
Journal of Radioimmanology
关键词
冠心病
内皮素-1
颗粒膜蛋白-140
妊娠相关蛋白A
稳定性心绞痛
不稳定性心绞痛
急性心肌梗死
coronary heart disease（CHD）
endothelin-1（ET-1）
granular membraneous protein-140（GMP-140）
pregnancy associated plasma protein-A（PAPP-A）
stable angina pectoris（SAP）
unstable angina pectoris（UAP）
acute myocardial infarction（AMI）
