糖尿病患者血浆CRP浓度与糖尿病血管病变的相关分析

Correlative Analysis on Plasma C-reactive Protein Concentration with Diabetes Mellitus Associated-vascular Disease in Patients with Diabetes Mellitus

目的:揭示2型糖尿病(DM2)患者血浆C-反应蛋白(CRP)浓度,探讨其对糖尿病血管病变的诊断价值。方法:对50例健康体检正常者和126例DM2患者,用ELISA检测血浆CRP浓度,统计分析其与糖尿病血管病变的相关性。结果:糖尿病患者血浆CRP浓度(7.48±3.26)mg/L较健康体检正常者(1.41±0.71)mg/L显著升高(P<0.01);糖尿病血管病变患者血浆CRP浓度(11.27±3.19)mg/L较糖尿病非血管病变患者(5.61±2.26)mg/L显著升高(P<0.01)。Logistic回归显示,血浆CRP浓度(OR=3.141,95%CI=1.431～11.316,P<0.01)是糖尿病并发血管病变的独立危险因素。ROC曲线分析显示,血浆CRP浓度对糖尿病并发血管病变有显著诊断价值(曲线下面积=0.849,95%CI=0.779～0.902,P<0.01),且判定血浆CRP浓度>8.36 mg/L,对诊断糖尿病并发血管病变有85.7%的灵敏度和76.9%的特异度。结论:CRP可能参与糖尿病血管病变的血管内皮损伤过程,血浆CRP浓度对于DM2并发血管病变,可提供作为一敏感的诊断标志物。

Objective To explore the determination of plasma C-reactive protein level in patients with type 2 diabetes mellitus and to evaluate its diagnostic value for diabetes mellitus associated-vascular disease.Methods 50 healthy controls and 126 patients with type 2 diabetes mellitus were included.Concentration of plasma C-reactive protein was measured with ELISA.It association with vascular disease were analyzed statistically.Results Plasma C-reactive protein level was obviously higher in patients than that in healthy controls（7.48±3.26 mg/L vs 1.41±0.71 mg/L,P0.01）and in patients with vascular disease than without that（11.27±3.19 mg/L vs 5.61±2.26 mg/L,P0.01）.On a multivariate logistic regression,plasma C-reactive protein level（OR=3.141,95%CI=1.431~11.316,P0.01） was an independent variable diagnosing vascular disease.A receiver operating characteristic curve identified that a plasma C-reactive protein level 8.36 mg/L diagnosed vascular disease with 85.7% sensitivity and 76.9% specificity（area under curve=0.849,95%CI=0.779~0.902,P0.01） discretery.Conclusion C-reactive protein maybe involved in endothelial injury of diabetes mellitus associated-vascular disease.Its plasma level can be served as sensitive diagnostic marker for diabetes mellitus associated-vascular disease.