米非司酮治疗围绝经期功能性子宫出血的临床观察

Clinical Observation on Mifepristone in Treatment of Perimenopausal Dysfunctional Uterine Bleeding

目的：探讨米非司酮治疗围绝经期功能性子宫出血的临床效果．方法：选择2010—05，2011-06就诊于内蒙古通辽市经济技术开发区河西镇卫生院妇产科的围绝经期功能性子宫出血患者36例，121服米非司酮片10mg日一次服用，连续3个月为1个疗程．结果：患者治疗期间均出现闭经，总有效率为100％．治疗后患者血清雌二醇、孕酮水平较治疗前明显下降（P〈0．05）．结论：米非司酮治疗围绝经期功能失调性子宫出血效果明显，安全可靠，无明显副作用，值得在临床上推广应用．

Objective： To investigate the clinical effects of mifepristone in the treatment of perimenopausal dysfunction- al uterine bleeding. Methods： 36 perimenopausal dysfunctional uterine bleeding patients who treated in our hospital fromSep. 2010 to June 2011 were selected, and orally given mifepristone tablets, 10 mg once a day, and three consecu- tive months was a course. Results： Amenorrhea appeared in all patients during treatment, the total effective rate was 100%. After treatment the patients serum estradiol and progesterone levels decreased significantly （P〈0.05） than be- fore treatment. Conclusion： Mifepristone has advantages of obvious effect, safety, reliability, no significant side effects in treatment of perimenopausal dysfunctional uterine bleeding, and worthy of clinical application.