N,N-二异丙基乙二胺的合成

Synthesis of N,N-diisopropylethane-1,2-diamine

目的合成得到N,N-二异丙基乙二胺,以降低生产成本。方法以二异丙胺和丙烯酰胺为起始原料,经Michael加成和Hofmann降解两步反应合成得到目标化合物。结果目标化合物总收率为55.3%,经核磁共振氢谱确证结构正确。结论该方法操作简单,原料廉价易得,适合工业化生产。

Objective To synthesize N, N - diisopropylethane - 1,2 - diamine in order to reduce production cost. Methods N,N- diisopropylethane- 1,2 -diamine was synthesized from diisopropylamine and acrylamide through Michael addition and Hofmann rearrangement reactions. Results The total yield of the target compound was 55.3% and the structure was confirmed by 1^H - NMR. Conclusions This method was easy to operate and had cheap raw materials, and it was suitable for industrial production.