IL-18与原发性高血压左室肥厚的相关性研究

Study on Association of Interleukin-18 Levels with Left Ventricular Hypertrophy in Essential Hypertension Patients

目的:探讨白细胞介素-18(IL-18)与原发性高血压左心室肥厚(LVH)的关系,以及IL-18在高血压左心室肥厚发病中的作用机制。方法:60例原发性高血压患者及30名健康者均行彩色超声心动图检查并计算左心室质量指数(LVMI),用ELISA法测定血清IL-18水平。结果:高血压组3个不同分级组血清IL-18水平均明显高于对照组(P<0.05);高血压组3个不同分级组间血清IL-18水平差异有统计学意义(P<0.05);高血压左心室肥厚组IL-18水平明显高于无左心室肥厚组(P<0.05),且与心肌肥厚指数成显著正相关(γ=0.52,P<0.05)。结论:IL-18可能参与了原发性高血压的病理生理过程及左心室肥厚的形成。

Objective：To investigate the relationship of levels of serum lnterleukin-18 （IL-18） with essential hypertension （EH） and left ventfieular hypertrophy（LVH） in patients.Methods：The value of left ventrieular mass of 30 normal individuals and 60 patients with EH were evaluated by Doppler echocardiography.The serum levels of IL-18 were measured by ELISA method.Results：The serum levels of IL-18 in patients with EH were significantly higher than that in normal individuals （P 〈0.05） .There were significant difference in the levels of IL- 18 among the 3 clinical grading of EH （P 〈0.05） .The levels of IL- 18 were higher in LVH group than that in NLVH group （P 〈0.05）; and their levels had positive correlation with LVMI （γ= 0.52,P〈0.05）.Conclusion：IL-18 is probably involved in the pathophysiological vrocess of essential hvvertension and acts as important role in the occurrence and development of LVH.