肺癌患者同步放化疗期间症状群的调查研究

Analysis on Symptom Clusters in Patients with Lung Cancer Undergoing Concurrent Chemoradiation Therapy

目的调查分析肺癌患者同步放化疗期间症状群的发生及分布特征。方法采用M.D安德森症状评估量表中文版(MDASI-C)对141例同步放化疗的肺癌患者进行调查。Spearman相关分析用于症状间相关性的分析;主成分分析用于提取患者的症状群。结果同步放化疗的肺癌患者疲乏症状强度得分最高,为(6.1±2.0)分,疲乏症状发生频率亦最高,为95.7%;MDASI-C各症状间均存在正相关(P<0.01),相关系数为0.13～0.74;主成分分析显示存在3个症状群:消化道症状群、情感症状群和病感症状群,3个症状群的内部信度Cronbach'sα系数分别为0.84、0.80和0.82。结论肺癌患者同步放化疗期间存在不同的症状群,认识该症状群有助于医护人员准确预见并为建立干预措施提供参考,以减轻肺癌患者的症状负担,提高其生活质量。

Objective To analyze the prevalence and distribution of symptom clusters in patient with lung cancer undergoing concurrent chemoradiation therapy（CCRT）.Methods A total of 141 lung cancer patients undergoing CCRT were surveyed with a self designed demographic questionnaire and the Chinese version of the M.D Anderson symptom inventory（MDASI-C）.Spearman correlation was used to analyze the correlation of the symptoms and principal component analysis（PCA） was used to extract symptom clusters.Results Lung cancer patients undergoing CCRT had the highest score for the intensity of fatigue symptoms（6.1±2.0）,as well as the highest frequency of fatigue symptoms（95.7%）.MDASI-C showed that the symptoms were positively correlated with each other（P0.01） with correlation coefficient being 0.13~0.74.PCA identified three symptom clusters,which were digestive tract symptom clusters,emotion symptom clusters and sickness feeling symptom clusters,and the Cronbach′s alpha coefficients for the three symptom clusters were 0.84,0.80 and 0.82.Conclusion There are three symptom clusters in patients with lung cancer during CCRT.Recognition of these symptom clusters is useful for medical staff to assess and provide effective interventions,which are conducive to symptom control and prevention and the improvement of life quality.