骨肉瘤化疗耐药机制及逆转治疗的研究进展

Research progress of drug resistance mechanism on osteosarcoma chemotherapy and reverse treatment

骨肉瘤是常见的骨源性恶性肿瘤,化疗是其重要的治疗手段,但肿瘤耐药性的存在,成为骨肉瘤复发和治疗失败的重要原因。明确其耐药机制,有效预防或逆转骨肉瘤耐药是目前临床亟待解决的问题。本文将对骨肉瘤耐药机制及其逆转策略的研究进展作一综述。

Osteosarcoma is a sort of malignant commonly-seen osteogenic sarcomas,a better treatment for it is chemother apy.However,tumor drug resistance is a key factor causing recurrence of osteosarcoma and treatment failure.Therefore,clearly understand its drug resistance mechanism and further effectively prevent or reverse osteosarcoma＇s drug resistance are urgent problems needed to be solved in current clinic.The article is going to review on drug resistance mechanism of osteosarcoma and strategy for its reversal.