晚期恶性肿瘤中医疗效评价指标的筛选

Selecting of evaluation indicator for TCM response criteria on treating advanced malignant tumor

目的筛选晚期恶性肿瘤中医疗效标准的评价指标。方法采用中医或中西医结合治疗的晚期胃癌、晚期结直肠癌2份样本,以生存时间为因变量,以多种评价指标为自变量,进行Cox多因素回归分析,分别建立晚期胃癌、晚期结直肠癌生存预测模型,选择其独立预后因素作为晚期恶性肿瘤中医疗效标准的评价指标。结果根据Cox比例风险回归模型,晚期胃癌、晚期结直肠癌的独立预后因素均为瘤体大小、KPS评分、体质量及主症变化4项。结论瘤体大小、KPS评分、体质量及主症变化4项可作为中医疗效标准的评价指标。

Objective It is to select the evaluation indicator for TCM response criteria on treating advanced malignant tumor. Methods Two samples of advanced gastric cancer and colorectal cancer treated with TCM alone or TCM combined with western medicine were included in the study. The dependent variable was the survival time, the independent variable was the related factor, Cox model was used to analyze muhifactors, and then the survival prediction model of advanced gastric cancer and colorectal cancer were built up. The independent prognostic factors were selected as evaluation indicator for TCM response criteria on treating advanced malignant tumor. Results According to Cox regression analysis, changes in tumor size, KPS, weight and main symptoms were the four indepondent prognostic factors both in advanced gastric cancer and colorectal cancer. Conclusion Changes in tumor size, KPS, weight and main symptoms can be used as evaluation indicator for TCM response cri- teria.