氯吡格雷对不稳定型心绞痛患者肿瘤坏死因子α及白介素6的影响

The Impact on Tumor Necrosis Factor Alpha and Interleukin 6 of Clopidogrel for the Patients with Unstable Angina

目的观察氯吡格雷治疗不稳定型心绞痛(UAP)的疗效,以及对UAP患者血清肿瘤坏死因子α(TNF-α)、白介素6(IL-6)的影响。方法选择2010年1月—2012年1月来我院住院治疗的UAP患者100例作为研究对象,随机分成治疗组和对照组,各50例。对照组予以常规对症治疗;治疗组在对照组治疗的基础上给予氯吡格雷治疗,比较两组治疗后的疗效,以及两组治疗前后心绞痛发作频率及平均发作持续时间,两组患者治疗前后TNF-α、IL-6的变化情况。结果治疗组总有效率(96.0%)高于对照组(84.0%),差异有统计学意义(P<0.05)。两组患者均未见明显的不良反应。治疗2周后,治疗组患者心绞痛发作频率、平均发作持续时间均明显少于对照组,差异有统计学意义(P<0.05);TNF-α、IL-6均明显低于对照组,差异有统计学意义(P<0.05)。结论氯吡格雷治疗UAP疗效可靠,能改善患者的临床症状,抑制炎症反应,值得广泛推广和应用。

Objective To observe the efficacy of clopidogrel in the treatment of unstable angina, and to observe the changes of serum tumor necrosis factor alpha （TNF -α）, interleukin -6 （IL-6） patients with unstable angina. Methods In January 2010 to January 2012 treated in our hospital 100 cases of UAP as the object of study, the patients were randomly divided into treatment group and control group, 50 cases ifi each. The control group was given conventional symptomatic therapy; treat- ment group in the control group treated with clopidogrel treatment, compared the clinical effects in two groups after treatment, as well as the two groups before and after treatment of angina frequency and mean duration of seizures, two groups of patients before and after treatment with TNF -α, IL - 6 Change. Results The iotal effective rate of treatment group is 96. 0% higher than that of control group 84. 0%, the difference was statistically significant （P 〈0. 05）. Two groups of patients had no obvious adverse reaction. After 2 weeks of treatment, the treatment group patients with angina frequency, average duration were significantly less than that in the control group, the difference was statistically significant （P 〈 0. 05） ; TNF-α, IL - 6 group was significantly lower than the control group, the difference was statistically significant （P 〈 0. 05 ）. Conclusion Clopidogrel in the treatment of unstable angina is reliable, andcan improve patients＇ clinical symptoms, inhibiting the inflammatory response, and worthy of extensive promotion and application.