代谢综合征患者血清抵抗素水平与氧化应激的关系研究

Relationship between Serum Resistin Level and Oxidative Stress in Patients with Metabolic Syndrome

目的探讨代谢综合征(MS)患者血清抵抗素水平与氧化应激的相关性。方法收集2011年7—10月乌鲁木齐市天山区现场调查人群,依照纳入标准筛选MS患者36例(MS组),在同一调查人群中收集年龄、性别及民族与MS组匹配的健康者36例(对照组)。现场测定身高、体质量、腰围、臀围、血压,计算体质指数(BMI)及腰臀比(WHR);实验室检测空腹血糖(FPG)、血脂、抵抗素、空腹胰岛素(FINS)及氧化应激指标,并计算胰岛素抵抗指数(HOMA-IR)。应用SPSS 17.0统计软件对数据进行统计分析。结果与对照组比较,MS组患者的BMI、WHR、血压、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、FPG、FINS、HOMA-IR、抵抗素及丙二醛(MDA)水平均高于对照组,而高密度脂蛋白胆固醇(HDL-C)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)和维生素C(Vit C)水平则低于对照组,组间比较差异均有统计学意义(P<0.05)。Pearson相关分析显示,血清抵抗素水平与HOMA-IR、MDA呈正相关(r值分别为0.865和0.396,P<0.01),与GSH-Px、SOD呈负相关(r值分别为-0.460和-0.371,P<0.05),与Vit C无相关性(P>0.05)。结论 MS患者血清抵抗素、氧化应激水平均较健康者显著升高,二者可能共同参与IR的发病机制。

Objective To investigate the relationship between serum resistin levels and oxidative stress in patients with Metabolic Syndrome（MS）.Methods A total of 36 MS patients（MS group） were recruited from July to October 2011 in Tianshan district of Urumqi.Meanwhile,36 healthy people with matched age,sex and nationality in the same area were selected as control group.Height,weight,waist circumference,hip circumference,blood pressure,BMI and WHR were measured among these people.Besides,FPG,blood lipid,resistin,FINS and oxidative stress indicators were measured in laboratory.The HOMA-IR was also calculated.SPSS 17.0 statistical software was used to statistically analyze the data.Results Compared with control group,the BMI,WHR,blood pressure,TC,TG,LDL-C,FPG,FINS,HOMA-IR,resistin and MDA in MS group were significantly higher,but the HDL-C,SOD,GSH-Px and Vit C were significantly lower（P0.05）.Pearson correlation analysis showed that the resistin was positively correlated with HOMA-IR and MDA（r=0.865 and 0.396,P0.01）,but was negatively correlated with GSH-Px and SOD（r=-0.460 and-0.371,P0.05）,and not correlated with Vit C（P0.05）.Conclusion MS patients have higher serum resistin and oxidative stress levels than healthy people,indicating they may be involved in the pathogenesis of IR.