新型软聚硅酮泡沫敷料治疗鼻咽癌患者颈部放射性湿性脱皮的疗效及安全性观察

Effect of Mepilex Lite Dressing on Radiation-induced Moist Desquamation in Patients with Nasopharyngeal Carcinoma:Report of A New Soft Silicone Dressing

目的探讨新型软聚硅酮泡沫敷料(Mepilex Lite)治疗鼻咽癌放疗患者颈部放射性湿性脱皮的临床疗效,并观察其安全性。方法本研究为类实验研究,观察32例(观察组)首程放疗致湿性脱皮的鼻咽癌患者在常规护理的基础上配合使用Mepilex Lite的愈合时间,并与接受常规护理和美宝烧伤湿润膏的32例患者(对照组)进行比较。结果两组中位愈合时间估计值分别为6.000和9.000 d,其标准误分别为0.935和1.210,95%CI分别为(4.167,7.833)和(6.629,11.371),两组Kaplan-Meier生存曲线水平间的整体比较Log-Rank检验结果显示,两条治愈率曲线差异有统计学意义(χ2=7.810,P=0.005),可认为观察组的治愈率高于对照组,与对照组比较,观察组湿性脱皮愈合较快。观察组有1例因对敷料过敏删失。结论 Mepilex Lite治疗鼻咽癌患者放射性湿性脱皮效果好,有加快伤口愈合的作用,且临床应用安全。

Objective To investigate the effect of a new soft silicone dressing（Mepilex Lite） on radiation-induced moist desquamation in nasopharyngeal carcinoma（NPC） patients and evaluate its clinical safety.Methods A quasi-RCT was conducted.A total of 64 NPC patients with radiation-induced moist desquamation were divided into groups study（n=32,given Mepilex Lite treatment） and control（n=32,treated with standrad MEBO cream）.The healing time was compared between 2 groups.Results The medium healing time of groups study and control was 6.000 days,95%CI（4.167,7.833）,9.000 days,95%CI（6.629,11.371）,respectively,and their standard errors were 0.935,1.210,respectively.The Log-Rank test was performed to compare the Kaplan-Meier curves of 2 groups and it showed significant difference between 2 groups（χ2=7.810,P=0.005）.Compared with control group,the moist desquamation of study group had a higher healing rate and healed more quickly.Besides,1 case was found to be allergic to Mepilex Lite and censored.Conclusion The new soft silcone dressing Mepilex Lite is effective on radiation-induced moist desquamation and can shorten healing time safely.