丙泊酚与七氟醚麻醉在腹腔镜胆囊切除术中应用效果的对照研究

Comparative study of propofol and sevoflurane in anesthesia of laparoscopic cholecystectomy

目的:对比分析丙泊酚与七氟醚麻醉在腹腔镜胆囊切除术中的应用效果。方法:回顾分析2009年2月至2012年3月为62例患者行腹腔镜胆囊切除术的临床资料,随机分为实验组与对照组。对照组采用瑞芬太尼与丙泊酚联合麻醉,观察组采用瑞芬太尼与七氟醚联合麻醉,对比分析两组患者应用效果。结果:实验组患者于气管插管后1 min、建立人工气腹前及建立人工气腹后5 min舒张压、收缩压及心率明显低于对照组,差异有统计学意义(P<0.05)。两组患者在自主呼吸恢复、睁眼、拔管及定向力恢复用时等方面差异无统计学意义(P>0.05)。结论:丙泊酚与七氟醚在腹腔镜胆囊切除术中的麻醉效果均较显著,但七氟醚麻醉可降低CO2气腹对患者产生的影响,能更平稳地维持患者的生命体征。

Objective：To compare the effect of propofol and sevoflurane in anesthesia of laparoscopic cholecystectomy.Methods：The clinical data of 62 patients who underwent laparoscopic cholecystectomy from Feb.2009 to Mar.2012 were retrospectively analyzed.The patients were randomly divided to two groups.In the control group,remifentanil and propofol were used and remifentanil and sevoflurane were used in the experimental group for combined anesthesia.The effects were comparatively studied.Results：The diastolic pressure,systolic pressure and heart rate in the experimental group were significantly lower than those in the control group at 1min after endotracheal intubation,before establishment of artificial pneumoperitoneum and 5min after establishment of artificial pneumoperitoneum（P0.05）.There were no significant differences in spontaneous breathing recovery,goggling,extubation and orientation recovery time（P0.05）.Conclusions：Both propofol and sevoflurane have obvious anesthesia effect.However,sevoflurane could decrease the effect of impact of CO2 pneumoperitoneum on patients and maintain the vital signs more steadily.